Skeletal muscle aging and the mitochondrion

被引：168

作者：

Johnson, Matthew L. ^{[1
]}

Robinson, Matthew M. ^{[1
]}

Nair, K. Sreekumaran ^{[1
]}

机构：

[1] Mayo Clin, Div Endocrinol, Rochester, MN 55905 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2013年 / 24卷 / 05期

基金：

美国国家卫生研究院;

关键词：

sarcopenia; mitochondria; protein metabolism; protein synthesis; aging; ACTIVATED PROTEIN-KINASE; DNA-DELETION MUTATIONS; AGE-RELATED-CHANGES; CHAPERONE-MEDIATED AUTOPHAGY; GAMMA COACTIVATOR 1-ALPHA; OXYGEN SPECIES PRODUCTION; OXIDATIVE CAPACITY; IN-VIVO; QUALITY-CONTROL; RESISTANCE EXERCISE;

D O I：

10.1016/j.tem.2012.12.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging process. A growing body of research in the areas of bioenergetics and protein turnover has placed the mitochondria at the center of this process. It is now clear that, unless an active lifestyle is rigorously followed, skeletal muscle mitochondrial decline occurs as humans age. Increasing research on mitochondrial biology has elucidated the regulatory pathways involved in mitochondrial biogenesis, many of which are potential therapeutic targets, and highlight the beneficial effects of vigorous physical activity on skeletal muscle health for an aging population.

引用

页码：247 / 256

页数：10

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