The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: II. Estimation of Bone Marrow Doses

被引:29
作者
Chumak, Vadim V. [1 ]
Romanenko, Anatoly Ye. [1 ]
Voilleque, Paul G. [2 ]
Bakhanova, Elena V. [1 ]
Gudzenko, Natalya [1 ]
Hatch, Maureen [3 ]
Zablotska, Lydia B. [4 ]
Golovanov, Ivan A. [5 ]
Luckyanov, Nickolas K.
Sholom, Sergey V. [1 ]
Kryuchkov, Viktor P. [5 ]
Bouville, Andre [3 ]
机构
[1] Ukraine Acad Med Sci, Res Ctr Radiat Med, UA-04050 Kiev, Ukraine
[2] MJP Risk Assessment Inc, Denver, CO USA
[3] NCI, DHHS, NIH, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
[4] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA
[5] Fed Res Ctr Inst Biophys, Moscow, Russia
关键词
D O I
10.1667/RR1403.1
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
After the accident that took place on 26 April 1986 at the Chornobyl nuclear power plant, hundreds of thousands of cleanup workers were involved in emergency measures and decontamination activities. In the framework of an epidemiological study of leukemia and other related blood diseases among Ukrainian cleanup workers, individual bone marrow doses have been estimated for 572 cases and controls. Because dose records were available for only about half of the study subjects, a time-and-motion method of dose reconstruction that would be applicable to all study subjects, whether dead or alive, was developed. The doses were calculated in a stochastic mode, thus providing estimates of uncertainties. The arithmetic mean individual bone marrow doses were found to range from 0.00004 to 3,300 mGy, with an average value of 87 mGy over the 572 study subjects. The uncertainties, characterized by the geometric standard deviation of the probability distribution of the individual dose, varied from subject to subject and had a median value of about 2. These results should be treated as preliminary; it is likely that the dose calculations and particularly the uncertainty estimates will be improved in the follow-up of this effort. (C) 2008 by Radiation Research Society
引用
收藏
页码:698 / 710
页数:13
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