The role of circadian rhythm in osteoporosis; a review

被引：16

作者：

Tian, Yihao ^{[1
]}

Ming, Jian ^{[1
]}

机构：

[1] Gen Hosp Northern Theater Command, Dept Pathol, Shenyang, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷

关键词：

circadian rhythm; melatonin; osteoclast differentiation; circadian rhythm genes; osteoporosis; BONE TURNOVER MARKERS; MINERAL DENSITY; CIRCULATING OSTEOPROTEGERIN; DIURNAL RHYTHMS; DOWN-REGULATION; SERUM CORTISOL; SOLUBLE RANKL; CLOCK; MELATONIN; RESORPTION;

D O I：

10.3389/fcell.2022.960456

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Osteoporosis is characterized by a high incidence rate, with significant effects on people's lives. The underlying mechanisms are complex, with no treatments for the condition. Recent studies have indicated that melatonin can be used to treat osteoporosis by promoting osteoblast proliferation and differentiation, and inhibiting osteoclast differentiation. Specifically, in vivo mechanisms are initiated by stabilizing biological rhythms in bone tissue. In healthy organisms, these biological rhythms are present in bone tissue, and are characterized by bone formation during the day, and bone resorption at night. When this rhythm is disrupted, osteoporosis occurs. Thus, taking appropriate medication at different times of the day could produce different effects on osteoporosis rhythms. In this review, we characterized these processes, and provided treatments and management strategies for individuals with osteoporosis.

引用

页数：13

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