Citrifelins A and B, Citrinin Adducts with a Tetracyclic Framework from Cocultures of Marine-Derived Isolates of Penicillium citrinum and Beauveria felina

被引：55

作者：

Meng, Ling-Hong ^{[1
,2
]}

Liu, Yang ^{[1
,2
]}

Li, Xiao-Ming ^{[1
]}

Xu, Gang-Ming ^{[1
]}

Ji, Nai-Yun ^{[3
]}

Wang, Bin-Gui ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2015年 / 78卷 / 09期

基金：

中国国家自然科学基金;

关键词：

NATURAL-PRODUCTS;

D O I：

10.1021/acs.jnatprod.5b00450

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Citrifelins A (1) and B (2), two citrinin adducts possessing a unique tetracyclic framework, were characterized from a coculture of marine-derived fungal isolates of Penicillium citrinum and Beauveria felina. Neither fungus produced these compounds when cultured alone under the same conditions. The structures of these adducts were elucidated on the basis of spectroscopic analysis, and the absolute configurations were assigned on the basis of TDDFT-ECD calculations. A hypothesis that adducts 1 and 2 might be derived from a citrinin derivative through a non-pericyclic Michael reaction is proposed. Compounds 1, 2, and 5 showed inhibitory activities against several human and aquatic pathogens.

引用

页码：2301 / 2305

页数：5

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