Molecular characterization of chromosomal band 5p15.33: A recurrent breakpoint region in mantle cell lymphoma involving the TERT-CLPTM1L locus

被引：12

作者：

Schilling, Georgia ^{[1
]}

Penas, Eva Maria Murga ^{[1
]}

Janjetovic, Snjezana ^{[1
]}

Oliveira-Ferrer, Leticia ^{[1
]}

Braig, Melanie ^{[1
]}

Behrmann, Petra ^{[1
]}

Bokemeyer, Carsten ^{[1
]}

Dierlamm, Judith ^{[1
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Univ Canc Ctr Hamburg, Hubertus Wald Tumorzentrum, Dept Oncol,BMT Sect Pneumol, D-20246 Hamburg, Germany

来源：

LEUKEMIA RESEARCH | 2013年 / 37卷 / 03期

关键词：

Mantle cell lymphoma; Secondary chromosomal aberrations; 5p15; TERT; CLPTM1L; LINE; GENERATION; VARIANTS; PATTERNS; LENGTH; GENE; TERT;

D O I：

10.1016/j.leukres.2012.10.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Secondary chromosomal aberrations may contribute to the development of a malignant phenotype in mantle cell lymphoma. Chromosomal band 5p15.33 represents a new recurrent breakpoint in B-cell malignancies. We present a molecular cytogenetic study of 8 mantle cell lymphoma (MCL) cell lines and 23 patients with MCL to determine and characterize novel secondary aberrations. We detected new secondary recurrent rearrangements in all cell lines and in 7 patients and confirmed 5p15.33 as a recurrent breakpoint in 4 cell lines and one patient. Further molecular characterization by flow-FISH and quantitative RT-PCR suggest TERT and CLPTM1L as target genes of 5p15.33 rearrangements. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：280 / 286

页数：7

共 29 条

[1]

ABE M, 1988, CANCER-AM CANCER SOC, V61, P483, DOI 10.1002/1097-0142(19880201)61:3<483::AID-CNCR2820610313>3.0.CO

[2]

2-L

[3] Flow cytometry and FISH to measure the average length of telomeres (flow FISH) [J].