Synthesis of functionalized benzannulated compounds

被引:5
作者
Condon, Sylvie [1 ]
El Ouarradli, Arnane [1 ]
Metay, Estelle [1 ]
Leonel, Eric [1 ]
Bourdonneau, Maryse [2 ]
Nedelec, Jean-Yves [1 ]
机构
[1] Univ Paris Est, Inst Chim & Mat, Paris Est UMR CNRS 7182, Equipe Electrochim Synth Organ, F-94320 Thiais, France
[2] Bruker Biospin SA, Lab Applicat RMN, F-67166 Wissembourg, France
关键词
D O I
10.1016/j.tet.2008.07.098
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Functionalized indane and naphthalene derivatives have been prepared according to two routes involving a nickel-catalyzed electrochemical arylation of activated olefins as the key step. The first method is a cascade process including the intramolecular nucleophilic addition of the first formed enolate intermediate. In the second method the cascade reaction is prevented by in situ protonation of the enolate, and the cyclization is further conducted chemically. This is an overall more efficient method than the first one, based on the electrochemical process. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:9388 / 9395
页数:8
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