Utility of Early High Dose Statins in Acute Coronary Syndrome

被引：2
作者：
Dougherty, Philip J. [1 ]
Arora, Rohit R. [1 ]
机构：
[1] Chicago Med Sch, Dept Cardiol, Chicago, IL USA
来源：
AMERICAN JOURNAL OF THERAPEUTICS | 2012年 / 19卷 / 05期
关键词：
acute coronary syndrome; statin; pleiotropic effects; high dose; early dose; COA REDUCTASE INHIBITORS; LOW-DENSITY-LIPOPROTEIN; LIPID-LOWERING THERAPY; ARTERY-DISEASE; HEART-DISEASE; MYOCARDIAL-INFARCTION; SAFETY; ATORVASTATIN; METAANALYSIS; EFFICACY;
D O I：
10.1097/MJT.0b013e31823735aa
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In accordance with the recommendations of the American College of Cardiology/American Heart Association Joint Task Force, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) are prescribed before hospital discharge after an episode of acute coronary syndrome. Yet, optimal timing and dosage have not been agreed upon. Recent evidence suggests a pleiotropic mechanism of action including vasoprotective, anti-inflammatory, and antiarrhythmic properties that imply an immediate role for statin medications. Our review suggests that early (<24 hours) high dose (80 mg of atorvastatin) statins may significantly reduce adverse cardiovascular outcomes and may improve long-term mortality.
引用
收藏
页码：369 / 376
页数：8
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