UHPLC-MS/MS method for iohexol determination in human EDTA and lithium-heparin plasma, human urine and in goat- and pig EDTA plasma

被引：7

作者：

Stevens, Jasper ^{[1
]}

Wessels, Mireille A. ^{[1
]}

Roggeveld, Jan ^{[1
]}

Koster, Remco A. ^{[1
,2
]}

Dekkers, Claire C. J. ^{[1
]}

van Gelder, Maaike K. ^{[3
]}

Gansevoort, Ron T. ^{[4
]}

Heerspink, Hiddo J. L. ^{[1
]}

Touw, Daan J. ^{[1
,5
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands

[2] PRA Hlth Sci, Bioanalyt Lab, Assen, Netherlands

[3] Univ Med Ctr Utrecht, Div Internal Med & Dermatol Nephrol & Hyperten, Utrecht, Netherlands

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands

[5] Univ Groningen, Groningen Res Inst Pharm, Dept Pharmaceut Anal, Groningen, Netherlands

来源：

BIOANALYSIS | 2020年 / 12卷 / 14期

关键词：

goat plasma; human plasma; human urine; iohexol; LC-MS; MS; pig plasma; GLOMERULAR-FILTRATION-RATE; PERFORMANCE;

D O I：

10.4155/bio-2020-0122

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Aim:Iohexol plasma clearance is used as an indicator of kidney function in clinical and preclinical settings. To investigate the pharmacokinetic profile of iohexol, a rapid, simple method for measurement of iohexol in different matrices and species was needed.Materials & methods:Iohexol was separated on an Accucore C18 column (Thermo Fisher Scientific, CA, USA). Detection was performed on a Thermo Scientific Quantiva tandem quadrupole mass spectrometer. The method was validated according to the requirements for bioanalytical methods issued by the US FDA and European Medicines Agency.Conclusion:We developed and validated a fast and efficient analytical method, suitable for analyzing iohexol in human EDTA plasma, human lithium-heparin plasma, human urine and goat- and pig EDTA plasma, using only one calibration line prepared in human EDTA plasma.

引用

页码：981 / 990

页数：10

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