Fatal BK virus pneumonia following stem cell transplantation

被引：21

作者：

Akazawa, Y. ^{[1
]}

Terada, Y. ^{[1
]}

Yamane, T. ^{[1
]}

Tanaka, S. ^{[1
]}

Aimoto, M. ^{[1
]}

Koh, H. ^{[1
]}

Nakane, T. ^{[1
]}

Koh, K. -R. ^{[1
]}

Nakamae, H. ^{[1
]}

Ohsawa, M. ^{[1
]}

Wakasa, K. ^{[1
]}

Hino, M. ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Med, Abeno Ku, Osaka 5458585, Japan

来源：

TRANSPLANT INFECTIOUS DISEASE | 2012年 / 14卷 / 06期

关键词：

BK virus pneumonia; hematopoietic stem cell transplantation; cidofovir; HEMORRHAGIC CYSTITIS; INFECTION; CIDOFOVIR; ASSOCIATION; BLOOD; LOAD;

D O I：

10.1111/tid.12011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report the case of a 39-year-old male patient who died of severe BK virus (BKV) pneumonia 168 days after hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia. After suffering from BKV-associated late-onset hemorrhagic cystitis (HC) with long-term sustained BKV viremia, he died of rapidly progressive pneumonia. On autopsy, numerous viral intranuclear inclusions were seen in his lungs and bladder. An immunohistochemical examination of his lungs was positive for simian virus 40. Based on these pathological results and the high sustained BKV viral load in his blood, we reached a diagnosis of BKV pneumonia. Viral infection can occasionally become life threatening among HSCT recipients. It is widely known that BKV can cause late-onset HC, but BKV-associated pneumonia is rare. Because of its rapid progression and poor prognosis, it is difficult to make an antemortem diagnosis of BKV pneumonia. A treatment strategy for BKV pneumonia also needs to be formulated. Similar to other viral pathogens, BKV can cause pneumonia and the clinician should therefore be aware of it in immunocompromised patients.

引用

页码：E142 / E146

页数：5

共 25 条

[21] Non-bacterial infections in allogeneic non-myeloablative stem cell transplant recipients [J].