From Genes to Environment: Using Integrative Genomics to Build a "Systems-Level" Understanding of Autism Spectrum Disorders

被引：34

作者：

Hu, Valerie W. ^{[1
]}

机构：

[1] George Washington Univ, Sch Med & Hlth Sci, Dept Biochem & Mol Biol, Washington, DC 20037 USA

来源：

CHILD DEVELOPMENT | 2013年 / 84卷 / 01期

关键词：

LYMPHOBLASTOID CELL-LINES; RECEPTOR ROR-ALPHA; FETAL VALPROATE SYNDROME; TRAIT LOCUS ANALYSIS; GASTROINTESTINAL SYMPTOMS; DNA-METHYLATION; SOCIAL DEFICITS; FAMILY-HISTORY; CHILDREN; EXPRESSION;

D O I：

10.1111/j.1467-8624.2012.01759.x

中图分类号：

G44 [教育心理学];

学科分类号：

0402 ; 040202 ;

摘要：

Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that affect an estimated 1 in 110 individuals. Although there is a strong genetic component associated with these disorders, this review focuses on the multifactorial nature of ASD and how different genome-wide (genomic) approaches contribute to our understanding of autism. Emphasis is placed on the need to study defined ASD phenotypes as well as to integrate large-scale omics data in order to develop a systems-level perspective of ASD, which in turn is necessary to allow predictions regarding responses to specific perturbations and interventions.

引用

页码：89 / 103

页数：15

共 120 条

[101]

Silverman JM, 2001, AM J MED GENET, V105, P593

[102] Autism and tuberous sclerosis [J].

Smalley, SL .

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 1998, 28 (05) :407-414

[103] Stratification based on language-related endophenotypes in autism:: Attempt to replicate reported linkage [J].

Spence, Sarah J. ;

Cantor, Rita M. ;

Chung, Lien ;

Kim, Sharon ;

Geschwind, Daniel H. ;

Alarcon, Maricela .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2006, 141B (06) :591-598

[104] staggerer phenotype in retinoid-related orphan receptor α-deficient mice [J].

Steinmayr, M ;

André, E ;

Conquet, F ;

Rondi-Reig, L ;

Delhaye-Bouchaud, N ;

Auclair, N ;

Daniel, H ;

Crépel, F ;

Mariani, J ;

Sotelo, C ;

Becker-André, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) :3960-3965

[105] Subgroups of children with autism by cluster analysis: A longitudinal examination [J].

Stevens, MC ;

Fein, DA ;

Dunn, M ;

Allen, D ;

Waterhouse, LH ;

Feinstein, C ;

Rapin, I .

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2000, 39 (03) :346-352

[106]

STROMLAND K, 1994, DEV MED CHILD NEUROL, V36, P351

[107] A principal components analysis of the autism diagnostic interview-revised [J].

Tadevosyan-Leyfer, O ;

Dowd, M ;

Mankoski, R ;

Winklosky, B ;

Putnam, S ;

McGrath, L ;

Tager-Flusberg, H ;

Folstein, SE .

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2003, 42 (07) :864-872

[108] Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice [J].

Takayanagi, Y ;

Yoshida, M ;

Bielsky, IF ;

Ross, HE ;

Kawamata, M ;

Onaka, T ;

Yanagisawa, T ;

Kimura, T ;

Matzuk, MM ;

Young, LJ ;

Nishimori, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (44) :16096-16101

[109] Feasibility and Relevance of Examining Lymphoblastoid Cell Lines to Study Role of microRNAs in Autism [J].

Talebizadeh, Zohreh ;

Butler, Merlin G. ;

Theodoro, Mariana F. .

AUTISM RESEARCH, 2008, 1 (04) :240-250

[110] A dimensional classification of autism spectrum disorder by social communication domains [J].

Tanguay, PE ;

Robertson, J ;

Derrick, A .

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1998, 37 (03) :271-277

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