Mechanical Control of Cell flow in Multicellular Spheroids

被引：56

作者：

Delarue, Morgan ^{[1
]}

Montel, Fabien ^{[2
]}

Caen, Ouriel ^{[3
]}

Elgeti, Jens ^{[4
,5
]}

Siaugue, Jean-Michel ^{[6
]}

Vignjevic, Danijela ^{[7
]}

Prost, Jacques ^{[1
,8
]}

Joanny, Jean-Francois ^{[1
]}

Cappello, Giovanni ^{[1
]}

机构：

[1] UPMC, Inst Curie, Ctr Rech, CNRS UMR168, F-75248 Paris 05, France

[2] Univ Paris Diderot, CNRS UMR 7057, MSC, F-75013 Paris, France

[3] Univ Paris Diderot, F-75013 Paris, France

[4] Forschungszentrum Julich, Inst Complex Syst, D-52425 Julich, Germany

[5] Forschungszentrum Julich, Inst Adv Simulat, D-52425 Julich, Germany

[6] Univ Paris 06, UMR 7195, PESCA, F-75006 Paris, France

[7] Inst Curie, UMR 144, Ctr Rech, F-75248 Paris 05, France

[8] Ecole Super Phys & Chim Ind Ville Paris, F-75005 Paris, France

来源：

PHYSICAL REVIEW LETTERS | 2013年 / 110卷 / 13期

关键词：

TUMOR SPHEROIDS; MIGRATION; INTERNALIZATION; MICROSPHERES; CANCER;

D O I：

10.1103/PhysRevLett.110.138103

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Collective cell motion is observed in a wide range of biological processes. In tumors, physiological gradients of nutrients, growth factors, or even oxygen give rise to gradients of proliferation. We show using fluorescently labeled particles that these gradients drive a velocity field resulting in a cellular flow in multicellular spheroids. Under mechanical stress, the cellular flow is drastically reduced. We describe the results with a hydrodynamic model that considers only convection of the particles by the cellular flow. DOI: 10.1103/PhysRevLett.110.138103

引用

页数：5

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