A Common Diaryl Ether Intermediate for the Gram-Scale Synthesis of Oxazine and Xanthene Fluorophores

被引：36

作者：

Anzalone, Andrew V. ^{[1
]}

Wang, Tracy Y. ^{[1
]}

Chen, Zhixing ^{[1
]}

Cornish, Virginia W. ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 02期

关键词：

copper; cyclization; domino reaction; dyes/pigments; fluorescence; FLUORESCENT-PROBE; ARYL HALIDES; SUPERRESOLUTION; RHODAMINES; CHEMISTRY;

D O I：

10.1002/anie.201205369

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Common ground: Copper-catalyzed coupling reactions can be used for the high-yielding preparation of widely used oxazine and xanthene fluorophores from a common diaryl ether intermediate on a gram-scale (see scheme). This general approach may facilitate the future development of novel fluorophores and probes with unique properties. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：650 / 654

页数：5

共 33 条

[11] REACTIONS OF SODIUM-BOROHYDRIDE IN ACIDIC MEDIA .1. REDUCTION OF INDOLES AND ALKYLATION OF AROMATIC-AMINES WITH CARBOXYLIC-ACIDS [J].