A Common Diaryl Ether Intermediate for the Gram-Scale Synthesis of Oxazine and Xanthene Fluorophores

被引：36
作者：
Anzalone, Andrew V. [1 ]
Wang, Tracy Y. [1 ]
Chen, Zhixing [1 ]
Cornish, Virginia W. [1 ]
机构：
[1] Columbia Univ, Dept Chem, New York, NY 10027 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 02期
关键词：
copper; cyclization; domino reaction; dyes/pigments; fluorescence; FLUORESCENT-PROBE; ARYL HALIDES; SUPERRESOLUTION; RHODAMINES; CHEMISTRY;
D O I：
10.1002/anie.201205369
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Common ground: Copper-catalyzed coupling reactions can be used for the high-yielding preparation of widely used oxazine and xanthene fluorophores from a common diaryl ether intermediate on a gram-scale (see scheme). This general approach may facilitate the future development of novel fluorophores and probes with unique properties. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：650 / 654
页数：5
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