An improved system for the palladium-catalyzed borylation of aryl halides with pinacol borane

被引：158

作者：

Billingsley, Kelvin L. ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 14期

关键词：

D O I：

10.1021/jo800727s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

borylation of aryl halides with an inexpensive and atom-economical boron source, pinacol borane, has been developed. This system allows for the conversion of aryl and heteroaryl iodides, bromides, and several chlorides, containing a variety of functional groups, to the corresponding pinacol boronate esters. In addition to the increase in substrate scope, this is the first general method where relatively low quantities of catalyst and short reaction times can be employed.

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收藏

页码：5589 / 5591

页数：3

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