A Self-Assembled Delivery Platform with Post-production Tunable Release Rate

被引：85
作者：
Boekhoven, Job [1 ]
Koot, Mathijs [1 ]
Wezendonk, Tim A. [1 ]
Eelkema, Rienk [1 ]
van Esch, Jan H. [1 ]
机构：
[1] Delft Univ Technol, Dept Chem Engn, NL-2628 BL Delft, Netherlands
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 31期
关键词：
DRUG-RELEASE; SENSITIVE LIPOSOMES; HYDROGELATORS; NANOSTRUCTURES; DOXORUBICIN; NANOFIBERS; MOLECULES; GELATOR; DESIGN;
D O I：
10.1021/ja3051876
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Self-assembly of three molecular components results in a delivery platform, the release rate of which can be tuned after its production. A fluorophore-conjugated gelator can be hydrolyzed by an enzyme, resulting in the release of a fluorescent small molecule. To allow the release to be tunable, the enzyme is entrapped in liposomes and can be liberated by heating the system for a short period. Crucially, the heating time determines the amount of enzyme liberated; with that, the release rate can be tuned by the time of heating.
引用
收藏
页码：12908 / 12911
页数：4
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