Crowning the Kinetochore: The Fibrous Corona in Chromosome Segregation

被引：44
|
作者：
Kops, Geert J. P. L. [1 ,2 ]
Gassmann, Reto [3 ,4 ]
机构：
[1] Hubrecht Inst KNAW, Oncode Inst, NL-3584 CT Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, NL-3584 CT Utrecht, Netherlands
[3] Univ Porto, Inst Biol Mol & Celular IBMC, P-4200135 Porto, Portugal
[4] Univ Porto, Inst Invest & Inovacao Saude i3S, P-4200135 Porto, Portugal
来源：
TRENDS IN CELL BIOLOGY | 2020年 / 30卷 / 08期
关键词：
SPINDLE ASSEMBLY CHECKPOINT; CENP-E; TRILAMINAR KINETOCHORE; FIBERS CONTRIBUTES; DYNEIN RECRUITMENT; RZZ COMPLEX; PTK2; CELLS; MICROTUBULE; ATTACHMENT; PROTEIN;
D O I：
10.1016/j.tcb.2020.04.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The kinetochore is at the heart of chromosome segregation in mitosis and meiosis. Rather than a static linker complex for chromatin and spindle microtubules, it is highly dynamic in composition, size, and shape. While known for decades that it can expand and grow a fibrous meshwork known as the corona, it was until recently unclear what constitutes this 'crown' and what its relevance is for kinetochore function. Here, we highlight recent discoveries in fibrous corona biology, and place them in the context of the processes that orchestrate high-fidelity chromosome segregation.
引用
收藏
页码：653 / 667
页数：15
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