The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study

被引：9

作者：

Dinh, Khoa M. ^{[1
]}

Pedersen, Ole B. ^{[2
]}

Petersen, Mikkel S. ^{[1
]}

Sorensen, Erik ^{[4
]}

Sorensen, Cecilie J. ^{[1
]}

Kaspersen, Kathrine A. ^{[1
]}

Larsen, Margit H. ^{[4
]}

Moller, Bjarne ^{[1
]}

Hjalgrim, Henrik ^{[3
]}

Ullum, Henrik ^{[4
]}

Erikstrup, Christian ^{[1
]}

机构：

[1] Aarhus Univ Hosp, Dept Clin Immunol, DK-8200 Aarhus N, Denmark

[2] Naestved Hosp, Dept Clin Immunol, DK-4700 Naestved, Denmark

[3] Statens Serums Inst, Dept Epidemiol Res, DK-2300 Copenhagen S, Denmark

[4] Rigshosp, Dept Clin Immunol, Copenhagen Univ Hosp, DK-2100 Copenhagen, Denmark

来源：

ATHEROSCLEROSIS | 2015年 / 242卷 / 01期

关键词：

CCR5; receptor; Genetics; Atherosclerosis; Inflammation; Cardiovascular diseases; Epidemiology; CORONARY-ARTERY-DISEASE; MYOCARDIAL-INFARCTION; HEART-DISEASE; CCR5; RISK; POLYMORPHISMS; SUSCEPTIBILITY; RECEPTORS; DIAGNOSES; MUTATION;

D O I：

10.1016/j.atherosclerosis.2015.07.031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and purpose: The C-C chemokine receptor 5-Delta 32 deletion (CCR5-Delta 32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Delta 32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors. Methods: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Delta 32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry. Results: CCR5-Delta 32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Delta 32 deletion. Conclusion: In this cohort, carriers of the CCR5-Delta 32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：222 / 225

页数：4

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