Neural Correlates of Unconsciousness in Large-Scale Brain Networks

被引:103
作者
Mashour, George A. [1 ]
Hudetz, Anthony G. [1 ]
机构
[1] Univ Michigan, Dept Anesthesiol, Neurosci Grad Program, Ctr Consciousness Sci,Med Sch, 1500 East Med Ctr Dr, Ann Arbor, MI 48109 USA
基金
美国国家卫生研究院;
关键词
PROPOFOL-INDUCED LOSS; CORTICAL EFFECTIVE CONNECTIVITY; FUNCTIONAL CONNECTIVITY; IMPAIRED CONSCIOUSNESS; ANESTHESIA; RECOVERY; KETAMINE; SYNCHRONIZATION; COMPLEXITY; DISRUPTION;
D O I
10.1016/j.tins.2018.01.003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The biological basis of consciousness is one of the most challenging and fundamental questions in 21st century science. A related pursuit aims to identify the neural correlates and causes of unconsciousness. We review current trends in the investigation of physiological, pharmacological, and pathological states of unconsciousness at the level of large-scale functional brain networks. We focus on the roles of brain connectivity, repertoire, graphtheoretical techniques, and neural dynamics in understanding the functional brain disconnections and reduced complexity that appear to characterize these states. Persistent questions in the field, such as distinguishing true correlates, linking neural scales, and understanding differential recovery patterns, are also addressed.
引用
收藏
页码:150 / 160
页数:11
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