Glutathione synthesis and its role in redox signaling

被引：182
作者：
Zhang, Hongqiao
Forman, Henry Jay [1 ,2 ]
机构：
[1] Univ So Calif, Davis Sch Gerontol, Los Angeles, CA 90089 USA
[2] Univ Calif Merced, Merced, CA 95343 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2012年 / 23卷 / 07期
基金：
美国国家卫生研究院;
关键词：
Glutathione; Redox signaling; Glutathionylation; GSNO; Nitrosylation; GLUTAMATE-CYSTEINE LIGASE; GAMMA-GLUTAMYLCYSTEINE SYNTHETASE; PROTEIN S-GLUTATHIONYLATION; NAD(P)H-QUINONE OXIDOREDUCTASE1 GENE; ELEMENT-MEDIATED EXPRESSION; TRANSCRIPTION FACTOR NRF2; PHASE-II GENES; NF-KAPPA-B; NITRIC-OXIDE; OXIDATIVE STRESS;
D O I：
10.1016/j.semcdb.2012.03.017
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Glutathione (GSH) is the most abundant antioxidant and a major detoxification agent in cells. It is synthesized through two-enzyme reaction catalyzed by glutamate cysteine ligase and glutathione synthetase, and its level is well regulated in response to redox change. Accumulating evidence suggests that GSH may play important roles in cell signaling. This review will focus on the biosynthesis of GSH, the reaction of S-glutathionylation (the conjugation of GSH with thiol residue on proteins), GSNO, and their roles in redox signaling. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：722 / 728
页数：7
相关论文
共 115 条
[1]   Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas [J].
Anathy, Vikas ;
Aesif, Scott W. ;
Guala, Amy S. ;
Havermans, Marije ;
Reynaert, Niki L. ;
Ho, Ye-Shih ;
Budd, Ralph C. ;
Janssen-Heininger, Yvonne M. W. .
JOURNAL OF CELL BIOLOGY, 2009, 184 (02) :241-252
[2]   S-glutathionylation decreases Mg2+ inhibition and S-nitrosylation enhances Ca2+ activation of RyR1 channels [J].
Aracena, P ;
Sánchez, G ;
Donoso, P ;
Hamilton, SL ;
Hidalgo, C .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (44) :42927-42935
[3]   HA-RAS AUGMENTS C-JUN ACTIVITY AND STIMULATES PHOSPHORYLATION OF ITS ACTIVATION DOMAIN [J].
BINETRUY, B ;
SMEAL, T ;
KARIN, M .
NATURE, 1991, 351 (6322) :122-127
[4]   Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression [J].
Bloom, DA ;
Jaiswal, AK .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (45) :44675-44682
[5]   THE ROLE OF CONJUGATION REACTIONS IN DETOXICATION [J].
BOCK, KW ;
LILIENBLUM, W ;
FISCHER, G ;
SCHIRMER, G ;
BOCKHENNIG, BS .
ARCHIVES OF TOXICOLOGY, 1987, 60 (1-3) :22-29
[6]   β3 Adrenergic Stimulation of the Cardiac Na+ -K+ Pump by Reversal of an Inhibitory Oxidative Modification [J].
Bundgaard, Henning ;
Liu, Chia-Chi ;
Garcia, Alvaro ;
Hamilton, Elisha J. ;
Huang, Yifei ;
Chia, Karin K. M. ;
Hunyor, Stephen N. ;
Figtree, Gemma A. ;
Rasmussen, Helge H. .
CIRCULATION, 2010, 122 (25) :2699-U209
[7]   Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity [J].
Cao, Juxiang ;
Schulte, Jennifer ;
Knight, Alexander ;
Leslie, Nicholas R. ;
Zagozdzon, Agnieszka ;
Bronson, Roderick ;
Manevich, Yefim ;
Beeson, Craig ;
Neumann, Carola A. .
EMBO JOURNAL, 2009, 28 (10) :1505-1517
[8]   S-nitrosothiol formation [J].
Carver, J ;
Doctor, A ;
Zaman, K ;
Gaston, B .
NITRIC OXIDE, PT E, 2005, 396 :95-105
[9]   Characterization of three isoforms of mammalian peroxiredoxin that reduce peroxides in the presence of thioredoxin [J].
Chae, HZ ;
Kim, HJ ;
Kang, SW ;
Rhee, SG .
DIABETES RESEARCH AND CLINICAL PRACTICE, 1999, 45 (2-3) :101-112
[10]   Glutaredoxin-1 regulates TRAF6 activation and the IL-1 receptor/TLR4 signalling [J].
Chantzoura, Eleni ;
Prinarakis, Efthimios ;
Panagopoulos, Dimitris ;
Mosialos, George ;
Spyrou, Giannis .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 403 (3-4) :335-339
12345678910