BASE CALLING ERROR RATES IN NEXT-GENERATION DNA SEQUENCING

被引：0
|
作者：
Shamaiah, Manohar [1 ]
Vikalo, Haris [1 ]
机构：
[1] Univ Texas Austin, Dept Elect & Comp Engn, Austin, TX 78712 USA
来源：
2012 IEEE STATISTICAL SIGNAL PROCESSING WORKSHOP (SSP) | 2012年
关键词：
ALGORITHM;
D O I：
暂无
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
We study the problem of base calling in next-generation DNA sequencing platforms that rely on reversible terminator chemistry. After reviewing a statistical model of the generated signal and the Viterbi algorithm for finding the maximum-likelihood solution to the base calling problem, we present a closed form expression for the upper bound on the probability of base calling error. Simulation results demonstrate that the derived upper bound provides a useful characterization of the error rate performance of the considered sequencing platform.
引用
收藏
页码：692 / 695
页数：4
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