Recruitment of the SWI/SNF chromatin remodeling complex by transcriptional activators

被引：200

作者：

Yudkovsky, N

Logie, C

Hahn, S

Peterson, CL ^{[1
]}

机构：

[1] Univ Massachusetts, Med Ctr, Program Mol Med, Worcester, MA 01605 USA

[2] Univ Massachusetts, Med Ctr, Dept Biochem & Mol Biol, Worcester, MA 01605 USA

[3] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

[4] Howard Hughes Med Inst, Seattle, WA 98109 USA

[5] Univ Washington, Mol & Cellular Biol Program, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA

来源：

GENES & DEVELOPMENT | 1999年 / 13卷 / 18期

关键词：

SWI-SNF; chromatin; transcription gene regulation; holoenzyme;

D O I：

10.1101/gad.13.18.2369

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

SWI/SNF is a chromatin remodeling complex that facilitates expression of a number of yeast genes. Here we demonstrate that SWI/SNF can be recruited from yeast nuclear extracts by a transcriptional activator. Recruitment is dependent on an activation domain but not on promoter sequences, TBP, or RNA polymerase II holoenzyme. We also show that acidic activation domains can target SWI/SNF remodeling activity. These results demonstrate that SWI/SNF activity can be targeted by gene-specific activators and that this recruitment can occur independently of Pol II holoenzyme.

引用

页码：2369 / 2374

页数：6

共 35 条

[21] Persistent site-specific remodeling of a nucleosome array by transient action of the SWI/SNF complex [J].