Anticonvulsant Activity of Dimephosphonum

被引：0
|
作者：
Abakumova, T. R. [1 ]
Karpenko, A. I. [1 ]
Khaziakhmetova, V. N. [1 ]
Ziganshina, L. E. [1 ]
机构：
[1] Kazanskij Federalnyj Univ, Inst Fundamentalnoj Med & Biol, Kazan, Russia
来源：
BIONANOSCIENCE | 2019年 / 9卷 / 02期
关键词：
Anticonvulsant activity; Dimephosphonum; Rats; Mice; Maximal electroshock test; Corazolum antagonism test; Anticonvulsant drugs;
D O I：
10.1007/s12668-019-0609-9
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
A novel Russian medicine dimephosphonum at its therapeutic doses of 50mg/kg and 100mg/kg showed anti-seizure activity on models of primary generalized seizures caused by corazolum or by maximal electroshock in rats and mice. Dimephosphonum prevented death of rats and mice in both seizure models like reference preparations phenazepam, valproic acid, and levetiracetam. The effects of dimephosphonum were less pronounced compared to phenazepam or valproic acid, but were comparable to those of levetiracetam.
引用
收藏
页码：235 / 237
页数：3
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