Preparation of cefazolin sodium liposomes by supercritical carbon dioxide method

被引：2

作者：

Yan, B ^{[1
]}

An, XQ ^{[1
]}

Bai, J ^{[1
]}

Zhang, YH ^{[1
]}

机构：

[1] Nanjing Normal Univ, Coll Chem & Environm Sci, Nanjing 210097, Peoples R China

来源：

ACTA PHYSICO-CHIMICA SINICA | 2006年 / 22卷 / 02期

关键词：

liposomes; cefazolin sodium; scCO(2); trapping efficiency; particle size; stability;

D O I：

10.3866/PKU.WHXB20060219

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The liposomes of cefazolin sodium were prepared using one step supercritical CO2 (scCO(2)) method. The size, stability, and trapping efficiency of liposomes were investigated. The experimental results demonstrate that the size and stability of liposomes depend on the pressure. The trapping efficiency of liposomes relates to the concentration of ethanol and lipid. The trapping efficiency by the scCO(2) method is much higher than the results from the Bangham method.

引用

页码：226 / 229

页数：4

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