Improved practical asymmetric synthesis of α-alkylmandelic acids utilizing highly diastereoselective alkylation of 5-aryl-2-(1-naphthyl)-1,3-dioxolan-4-ones

被引：16

作者：

Misaki, Tomonori ^{[1
]}

Ureshino, Satoko ^{[1
]}

Nagase, Ryohei ^{[1
]}

Oguni, Yumiko ^{[1
]}

Tanabe, Yoo ^{[1
]}

机构：

[1] Kwansei Gakuin Univ, Sch Sci & Technol, Dept Chem, Sanda, Hyogo 6691337, Japan

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2006年 / 10卷 / 03期

关键词：

D O I：

10.1021/op050263j

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A practical method for the synthesis of optically pure alpha-alkylmandelic acids 1 is described. The present improved robust method involved two reactions: a mild, convenient, stereoselective preparation of chiral cis-5-aryl-2-(1-naphthyl)-1,3-dioxolan- 4-ones, 9a-c, and highly diastereoselective alkylation of 9a-c, followed by the hydrolysis.

引用

页码：500 / 504

页数：5

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