Rat Cartilage Repair Using Nanophase PLGA/HA Composite and Mesenchymal Stem Cells

被引：29
作者：
Li, Huade [2 ]
Zheng, Qiang [2 ]
Xiao, Yuxiang [2 ]
Feng, Jie [1 ]
Shi, Zhongli [1 ]
Pan, Zhijun [1 ]
机构：
[1] Inst Orthopaed Res, Hangzhou 310009, Zhejiang, Peoples R China
[2] Zhejiang Univ, Dept Orthopaed, Affiliated Hosp 2, Coll Med, Hangzhou 310009, Zhejiang, Peoples R China
来源：
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 2009年 / 24卷 / 01期
关键词：
poly(lactide-co-glycolide); hydroxyapatite; PLGA/HA; tissue scaffolds; mesenchymal stem cells; cartilage repair; cartilage regeneration; tissue engineering; phenotype cells; BONE MORPHOGENETIC PROTEIN-2; ARTICULAR-CARTILAGE; CULTURED CHONDROCYTES; MECHANICAL-PROPERTIES; OSTEOCHONDRAL REPAIR; TISSUE; DEFECTS; MODEL; SCAFFOLDS; KNEE;
D O I：
10.1177/0883911508100655
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Biodegradable polymer/bioceramic composite poly(lactide-coglycolide)/hydroxyapatite(PLGA/HA) was studied for bone tissue engineering. The PLGA/HA composite was evaluated as a scaffold with the ability for mesenchymal stem cells (MSC) to participate in cartilage repair. The PLGA/HA composite and the PLGA/HA composite cultured with MSC were transplanted into cartilage defects created in rats. The PLGA/HA-MSC and PLGA/HA had better tissue morphology, structure integrity, matrix staining, and much thicker newly formed cartilage than the control group. The histological score for PLGA/HA-MSC better than that for PLGA/HA; it appears that the MSC plays an important role in tissue repair. Based on these results, using PLGA/HA as the tissue scaffold and the addition of MSC significantly enhances cartilage repair.
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收藏
页码：83 / 99
页数：17
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