De Novo structure determination from residual dipolar couplings by NMR spectroscopy

被引：0

作者：

Simon, B ^{[1
]}

Sattler, M ^{[1
]}

机构：

[1] European Mol Biol Lab, Struct & Computat Biol, D-69117 Heidelberg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 03期

关键词：

D O I：

10.1002/1521-3773(20020201)41:3<437::AID-ANIE437>3.0.CO;2-3

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The three-dimensional structures of biomacromolecules in solution can be determined with NMR spectroscopy. The use of residual dipolar couplings (RDCs) that can be measured in dilute liquid crystalline solution is currently revolutionizing the way structures are determined by NMR spectroscopy. This is highlighted by the recent de novo structure determination of the protein ubiquitin (see picture; liquid crystals are shown in green) using only RDC data.

引用

页码：437 / 440

页数：4

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