In vitro antiproliferative effect of a water-soluble Laminaria japonica polysaccharide on human melanoma cell line A375

被引：19

作者：

Peng, Zhenfei ^{[1
,2
]}

Liu, Min ^{[1
,2
]}

Fang, Zhexiang ^{[1
]}

Chen, Li ^{[1
]}

Wu, Jiulin ^{[1
]}

Zhang, Qiqing ^{[1
,3
,4
]}

机构：

[1] Fuzhou Univ, Inst Biomed & Pharmaceut Technol, Fuzhou 350002, Peoples R China

[2] Fuzhou Univ, Coll Chem & Chem Engn, Fuzhou 350002, Peoples R China

[3] Chinese Acad Med Sci, Inst Biomed Engn, Tianjin, Peoples R China

[4] Peking Union Med Coll, Tianjin, Peoples R China

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2013年 / 58卷

关键词：

Laminaria japonica polysaccharide; Antitumor activity; Apoptosis; Bcl-2 family proteins; A375; cells; SULFATED POLYSACCHARIDE; ANTITUMOR ACTIVITIES; ANTIOXIDANT; APOPTOSIS; IMMUNOMODULATION; FRACTIONS; GROWTH; CANCER; BCL-2; ALGA;

D O I：

10.1016/j.fct.2013.04.026

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

A water-soluble polysaccharide WPS-2-1, purified from Laminaria japonica, has been found to have antitumor activity. In this study, WPS-2-1 exhibited high anti-proliferative activity on A375 cells in a dose-dependent manner. Further investigation indicated that WPS-2-1 induced A375 cells apoptosis. Moreover, WPS-2-1-induced apoptosis was associated with the alteration in expressions of Bcl-2 family proteins. Mitochonadrial apoptotic pathway was involved in WPS-2-1-induced apoptosis, which included the loss of mitochondrial membrane and activation of caspase-3/9. The results in this study suggested that WPS-2-1 could effectively inhibit proliferation of A375 cells in vitro and induce apoptosis via mitochondrial apoptotic pathway. It might serve as a potential antitumor agent. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：56 / 60

页数：5

共 24 条

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