Serum lipoprotein (a) in diabetic patients with various renal function not yet on dialysis

To examine the association of serum serum lipoprotein(a)[Lp(a)] concentration with various demographic and biochemical indexes of diabetic patients, we conducted a study on type 2 diabetes mellitus(T2D) patients. Patients were under treatment with insulin injection or oral hypoglycemic agents with various creatinine clearances not yet on dialysis. We studied 122 patients, with a mean age of 63 +/- 10 years. The duration of diabetes was 7.4 +/- 5.8 years. In this cross-sectional study, serum Lp(a), HbA(1c), body mass index (BMI) and creatinine clearance were assessed. The mean serum Lp(a) was 22.2 +/- 24.7 mg/dL(median: 18.3 mg/dL), and serum Lp(a) levels more than 30 mg/dL was found in 29(23.8%) patients. A significant inverse correlation of serum Lp(a) with clearance of creatinine was observed. This study suggests that renal function is an independent determinant of serum Lp(a) in diabetic patients.