Update on tubulin-binding agents

被引：133
作者：
Attard, G
Greystoke, A
Kaye, S
De Bono, J
机构：
[1] Inst Canc Res, Sutton SM2 5PT, Surrey, England
[2] Royal Marsden Hosp, Sutton SM2 5PT, Surrey, England
来源：
PATHOLOGIE BIOLOGIE | 2006年 / 54卷 / 02期
关键词：
tubulin-binding; taxanes; vinca alkaloids; dolastations; vinflunine; combretastatin analogues;
D O I：
10.1016/j.patbio.2005.03.003
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The clinical and commercial success of the taxanes and vinca alkaloids resulted in a drive to improve on current formulations and discover new compounds that target the microtubule. These strategies are all aimed at improving on (1) anti-tumour activity, (2) toxicity profile and (3) pharmacology. Drugs undergoing clinical development include the novel semi-synthetic taxane derivatives (DJ-927, XRP6258 and XRP9881), the epothilones, the dolastations, vinflunine and the combretastatin analogues. In several cases, some improvements in tumour response rates have been seen but randomised trials need to be completed before the role of specific novel tubulin-binding agents can be established. (C) 2005 Elsevier SAS. All rights reserved.
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收藏
页码：72 / 84
页数：13
相关论文
共 127 条
[1]   Phase I trial and pharmacokinetic study of BMS-247550, an epothilone B analog, administered intravenously on a daily schedule for five days [J].
Abraham, J ;
Agrawal, M ;
Bakke, S ;
Rutt, A ;
Edgerly, M ;
Balis, FM ;
Widemann, B ;
Davis, L ;
Damle, B ;
Sonnichsen, D ;
Lebwohl, D ;
Bates, S ;
Kotz, H ;
Fojo, T .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (09) :1866-1873
[2]  
[Anonymous], P AM SOC CLIN ONCOL
[3]   INHIBITION OF GROWTH OF COLON-38 ADENOCARCINOMA BY VINBLASTINE AND COLCHICINE - EVIDENCE FOR A VASCULAR MECHANISM [J].
BAGULEY, BC ;
HOLDAWAY, KM ;
THOMSEN, LL ;
ZHUANG, L ;
ZWI, LJ .
EUROPEAN JOURNAL OF CANCER, 1991, 27 (04) :482-487
[4]  
BAI R, 1991, J BIOL CHEM, V266, P15882
[5]  
BAI R, 1990, J BIOL CHEM, V265, P17141
[6]   DOLASTATIN-15, A POTENT ANTIMITOTIC DEPSIPEPTIDE DERIVED FROM DOLABELLA-AURICULARIA - INTERACTION WITH TUBULIN AND EFFECTS ON CELLULAR MICROTUBULES [J].
BAI, R ;
FRIEDMAN, SJ ;
PETTIT, GR ;
HAMEL, E .
BIOCHEMICAL PHARMACOLOGY, 1992, 43 (12) :2637-2645
[7]  
Bapsy PP, 2004, J CLIN ONCOL, V22, p133S
[8]  
Beeram M, 2004, J CLIN ONCOL, V22, p207S
[9]  
Belotti D, 1996, CLIN CANCER RES, V2, P1843
[10]  
Bennouna J, 2004, J CLIN ONCOL, V22, p651S
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