Effect of the antiulcer polysaccharide fraction from Bupleurum falcatum L. on the healing of gastric ulcer induced by acetic acid in rats

被引：33
作者：
Matsumoto, T
Sun, XB
Hanawa, T
Kodaira, H
Ishii, K
Yamada, H
机构：
[1] Kitasato Inst, Oriental Med Res Ctr, Tokyo 108, Japan
[2] Kitasato Univ, Sch Pharmaceut Sci, Dept Mol Pharmacol, Tokyo 108, Japan
来源：
PHYTOTHERAPY RESEARCH | 2002年 / 16卷 / 01期
关键词：
acetic acid; chronic ulcer; antiulcer; polysaccharide; Bupleurum falcatum L;
D O I：
10.1002/ptr.986
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An antiulcer polysaccharide fraction (BR-2) from Bupleurum falcatum L. was examined for its effect on the healing of chronic ulcers induced by acetic acid in rats. When BR-2 was administered orally to the rats, it was shown to be effective in the healing of acetic acid-induced chronic ulcer. This result suggests that the use of herbal prescriptions containing B. falcatum L. may prove useful for the treatment of peptic ulcers. Copyright (C) 2002 John Wiley Sons, Ltd.
引用
收藏
页码：91 / 93
页数：3
相关论文
共 14 条
[1]   ANTIULCER ACTION AND TOXICITY OF STYRAX-CAMPORUM AND CAESALPINIA-FERREA [J].
BACCHI, EM ;
SERTIE, JAA ;
VILLA, N ;
KATZ, H .
PLANTA MEDICA, 1995, 61 (03) :204-207
[2]   STUDIES ON ANTIULCER PECTIC POLYSACCHARIDES FROM BUPLEURUM-FALCATUM .5. STRUCTURAL STUDIES OF ENDOPOLYGALACTURONASE RESISTANT FRAGMENTS OF AN ANTIULCER PECTIN FROM THE ROOTS OF BUPLEURUM-FALCATUM L [J].
HIRANO, M ;
KIYOHARA, H ;
MATSUMOTO, T ;
YAMADA, H .
CARBOHYDRATE RESEARCH, 1994, 251 :145-162
[3]   EFFECT OF CIMETIDINE AND OMEPRAZOLE ON GASTRIC-ULCER HEALING OF RATS WITH LIMITED FOOD-INTAKE TIME [J].
ITO, M ;
SEGAMI, T ;
TSUKAHARA, T ;
KOJIMA, R ;
SUZUKI, Y .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 263 (03) :245-251
[4]  
ITO M, 1984, EXPT ULCER RES TREND, P201
[5]  
Li Y, 1999, J PHARMACOL EXP THER, V290, P789
[6]  
Li Y, 1998, CHINESE MED J-PEKING, V111, P12
[7]   ROLE OF POLYMORPHONUCLEAR LEUKOCYTES AND OXYGEN-DERIVED FREE-RADICALS IN THE FORMATION OF GASTRIC-LESIONS INDUCED BY HCL/ETHANOL, AND A POSSIBLE MECHANISM OF PROTECTION BY ANTIULCER POLYSACCHARIDE [J].
MATSUMOTO, T ;
MORIGUCHI, R ;
YAMADA, H .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1993, 45 (06) :535-539
[8]   CHRONICITY OF ACETIC-ACID ULCER IN RAT STOMACH [J].
OKABE, S ;
PFEIFFER, CJ .
AMERICAN JOURNAL OF DIGESTIVE DISEASES, 1972, 17 (07) :619-&
[9]   Detection and tissue distribution of anti-ulcer pectic polysaccharides from Bupleurum falcatum by polyclonal antibody [J].
Sakurai, MH ;
Matsumoto, T ;
Kiyohara, H ;
Yamada, H .
PLANTA MEDICA, 1996, 62 (04) :341-346
[10]   EFFECTS OF A POLYSACCHARIDE FRACTION FROM THE ROOTS OF BUPLEURUM-FALCATUM L ON EXPERIMENTAL GASTRIC-ULCER MODELS IN RATS AND MICE [J].
SUN, XB ;
MATSUMOTO, T ;
YAMADA, H .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1991, 43 (10) :699-704
12