The aging of lympho-hematopoietic stem cells

被引：172

作者：

Geiger, H

Van Zant, G ^{[1
]}

机构：

[1] Univ Kentucky, Dept Med, Lexington, KY 40536 USA

[2] Univ Kentucky, Dept Physiol, Lexington, KY 40536 USA

来源：

NATURE IMMUNOLOGY | 2002年 / 3卷 / 04期

关键词：

D O I：

10.1038/ni0402-329

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The extensive self-renewal capacity of hematopoietic stem cells (HSCs) implies that this cell population may not age and thus may provide undiminished replenishment of blood cells throughout the lifespan of an organism. In contrast, accumulating experimental evidence supports the premise that HSCs show signs of aging and may have a limited functional lifespan. We summarize here the evidence for HSC aging, discuss the possible molecular mechanisms that may be involved and show evidence of a genetic connection between the effects of age on blood-forming cells and the longevity of mice. We speculate that age-related functional decline in adult tissue HSCs limits longevity in mammals.

引用

页码：329 / 333

页数：5

共 65 条

[1] Age-associated thymic atrophy is linked to a decline in IL-7 production [J].