Serum lipid profile in psoriatic patients: correlation between vascular adhesion protein 1 and lipoprotein (a)

被引:22
作者
Nemati, Houshang [1 ,2 ]
Khodarahmi, Reza [1 ,2 ]
Rahmani, Ameneh [2 ]
Ebrahimi, Ali [3 ]
Amani, Mojtaba [4 ]
Eftekhari, Kamran [2 ]
机构
[1] Kermanshah Univ Med Sci, Fac Pharm, Kermanshah, Iran
[2] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran
[3] Kermanshah Univ Med Sci, Fac Med, Kermanshah, Iran
[4] Ardabil Univ Med Sci, Fac Med, Ardebil, Iran
关键词
psoriasis; lipids; apolipoproteins; Lp(a); VAP-1; LOW-DENSITY-LIPOPROTEIN; QUALITY-OF-LIFE; LYMPHOCYTE BINDING; SKIN; RISK; RECEPTORS; ARTHRITIS; DISEASE; VAP-1;
D O I
10.1002/cbf.2857
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Psoriasis is a chronic inflammatory skin disease characterized by excessive cellular replication. Apolipoproteins are genetically determined molecule whose role has been implied in cardiovascular pathology. Vascular adhesion protein-1 (VAP-1) is an adhesion molecule with an enzymatic activity that partakes in the migration process of lymphocytes into sites of inflammation. Our purpose was to evaluate the plasma lipid profiles, apolipoproteins (A1, B) and Lp (a) and VAP-1 in order to compare the lipid profile in psoriatic patients with non-affected persons and correlation between VAP-1 and Lp (a). We determined serum concentrations of lipids, lipoproteins , apolipoproteins and VAP-1 in 90 patients with psoriasis and 90 age matched controls. Serum Lp (a), apo A1 and apo B were measured by immunoprecipitation assays, and the lipids and lipoproteins were measured by enzymatic methods.The VAP-1 were masured by ELISA method. The mean levels of total cholesterol, LDL, apo B and VAP-1 in patients with psoriasis were found to be significantly higher than those of healthy subjects (P<0.05. In psoriatic patients, elevation of VAP-1 correlated with elevation of Lp (a) (p?=?0.025). This study shows that high serum lipid level and VAP-1, is significantly more common in psoriasis. This fact may be responsible for higher prevalence of cardiovascular accident in psoriatic patients. Copyright (c) 2012 John Wiley & Sons, Ltd.
引用
收藏
页码:36 / 40
页数:5
相关论文
共 47 条
[1]   Psoriasis is associated with clinically significant cardiovascular risk: a Danish nationwide cohort study [J].
Ahlehoff, O. ;
Gislason, G. H. ;
Charlot, M. ;
Jorgensen, C. H. ;
Lindhardsen, J. ;
Olesen, J. B. ;
Abildstrom, S. Z. ;
Skov, L. ;
Torp-Pedersen, C. ;
Hansen, P. R. .
JOURNAL OF INTERNAL MEDICINE, 2011, 270 (02) :147-157
[2]   Lymphocyte binding to vascular endothelium in inflamed skin revisited: A central role for vascular adhesion protein-1 (VAP-1) [J].
Arvilommi, AM ;
Salmi, M ;
Kalimo, K ;
Jalkanen, S .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (04) :825-833
[3]  
Assous N, 2007, REV RHUM, V74, P72
[4]   The importance of non-HDL cholesterol reporting in lipid management [J].
Blaha, Michael J. ;
Blumenthal, Roger S. ;
Brinton, Eliot A. ;
Jacobson, Terry A. .
JOURNAL OF CLINICAL LIPIDOLOGY, 2008, 2 (04) :267-273
[5]   SOLUBLE E-SELECTIN AND SOLUBLE TUMOR-NECROSIS-FACTOR RECEPTOR (60-KD) SERUM LEVELS IN PATIENTS WITH PSORIASIS [J].
BONIFATI, C ;
TRENTO, E ;
CARDUCCI, M ;
SACERDOTI, G ;
MUSSI, A ;
FAZIO, M ;
AMEGLIO, F .
DERMATOLOGY, 1995, 190 (02) :128-131
[6]   Lymphocyte homing and homeostasis [J].
Butcher, EC ;
Picker, LJ .
SCIENCE, 1996, 272 (5258) :60-66
[7]  
Carducci Massimo, 1995, Journal of Dermatology (Tokyo), V22, P475
[8]   INCIDENCE OF CORONARY HEART-DISEASE AND LIPOPROTEIN CHOLESTEROL LEVELS - THE FRAMINGHAM-STUDY [J].
CASTELLI, WP ;
GARRISON, RJ ;
WILSON, PWF ;
ABBOTT, RD ;
KALOUSDIAN, S ;
KANNEL, WB .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1986, 256 (20) :2835-2838
[9]   Comorbidities in psoriasis [J].
Christophers, Enno .
CLINICS IN DERMATOLOGY, 2007, 25 (06) :529-534
[10]   Serum lipid level in Iranian patients with psoriasis [J].
Farshchian, M. ;
Zamanian, A. ;
Farshchian, M. ;
Monsef, A-R ;
Mahjub, H. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2007, 21 (06) :802-805