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Fibroblasts Rendered Antifibrotic, Antiapoptotic, and Angiogenic by Priming With Cardiosphere-Derived Extracellular Membrane Vesicles
被引:132
作者:

Tseliou, Eleni
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机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Fouad, Joseph
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h-index: 0
机构:
Harvard Univ, Boston, MA USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Reich, Heidi
论文数: 0 引用数: 0
h-index: 0
机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Slipczuk, Leandro
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机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

de Couto, Geoffrey
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机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Aminzadeh, Mark
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h-index: 0
机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Middleton, Ryan
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h-index: 0
机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Valle, Jackelyn
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h-index: 0
机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Liu Weixin
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h-index: 0
机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Marban, Eduardo
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h-index: 0
机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA
机构:
[1] Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA
[2] Harvard Univ, Boston, MA USA
关键词:
cardiac repair;
conversion;
exosome;
growth factor;
STEM-CELLS;
MYOCARDIAL-INFARCTION;
CARDIAC-FUNCTION;
EXOSOMES;
CARDIOMYOCYTES;
REGENERATION;
MICRORNAS;
MEDIATE;
ROLES;
HEART;
D O I:
10.1016/j.jacc.2015.05.068
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
BACKGROUND Cardiosphere-derived cells mediate therapeutic regeneration in patients after myocardial infarction and are undergoing further clinical testing for cardiomyopathy. The beneficial effects of cardiosphere-derived cells are mediated by the secretion of exosomes and possibly other extracellular membrane vesicles (EMVs). OBJECTIVES This study sought to investigate the effect of cardiosphere-derived EMVs (CSp-EMVs) on fibroblasts in vitro and tested whether priming with CSp-EMVs could confer salutary properties on fibroblasts in vivo. METHODS CSp-EMVs were isolated from serum-free media conditioned for 3 days by cardiospheres. Dermal fibroblasts were primed with CSp-EMVs for 24 h followed by exosomal micro-ribonucleic acid profiling. In vivo, we injected CSp-EMV-primed or -unprimed dermal fibroblasts (or CSp-EMVs) in a chronic rat model of myocardial infarction and defined the functional and structural consequences. RESULTS CSp-EMVs amplified their own biological signals: exposure of "inert" fibroblasts to CSp-EMVs rendered the fibroblasts therapeutic. Intramyocardially injected CSp-EMV-primed (but not unprimed) fibroblasts increased global pump function and vessel density while reducing scar mass. CSp-EMV priming caused fibroblasts to secrete much higher levels of stromal-cell-derived factor 1 and vascular endothelial growth factor and dramatically changed the micro-ribonucleic acid profile of fibroblast-secreted EMVs in vitro. The priming was followed by significant angiogenic and cardioprotective effects. CONCLUSIONS CSp-EMVs alter fibroblast phenotype and secretome in a salutary positive-feedback loop. The phenotypic conversion of inert cells to therapeutically active cells reveals a novel mechanism for amplification of exosome bioactivity. (C) 2015 by the American College of Cardiology Foundation.
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页码:599 / 611
页数:13
相关论文
共 41 条
[1]
Induced regeneration-the progress and promise of direct reprogramming for heart repair
[J].
Addis, Russell C.
;
Epstein, Jonathan A.
.
NATURE MEDICINE,
2013, 19 (07)
:829-836

Addis, Russell C.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Dept Cell & Dev Biol, Perelman Sch Med, Inst Regenerat Med, Philadelphia, PA 19104 USA

Epstein, Jonathan A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Cell & Dev Biol, Perelman Sch Med, Inst Regenerat Med, Philadelphia, PA 19104 USA Univ Penn, Dept Cell & Dev Biol, Perelman Sch Med, Inst Regenerat Med, Philadelphia, PA 19104 USA
[2]
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
[J].
Alvarez-Erviti, Lydia
;
Seow, Yiqi
;
Yin, HaiFang
;
Betts, Corinne
;
Lakhal, Samira
;
Wood, Matthew J. A.
.
NATURE BIOTECHNOLOGY,
2011, 29 (04)
:341-U179

Alvarez-Erviti, Lydia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Physiol Anat & Genet, Oxford, England Univ Oxford, Dept Physiol Anat & Genet, Oxford, England

Seow, Yiqi
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Physiol Anat & Genet, Oxford, England Univ Oxford, Dept Physiol Anat & Genet, Oxford, England

Yin, HaiFang
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Physiol Anat & Genet, Oxford, England Univ Oxford, Dept Physiol Anat & Genet, Oxford, England

Betts, Corinne
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Physiol Anat & Genet, Oxford, England Univ Oxford, Dept Physiol Anat & Genet, Oxford, England

Lakhal, Samira
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Physiol Anat & Genet, Oxford, England Univ Oxford, Dept Physiol Anat & Genet, Oxford, England

Wood, Matthew J. A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Physiol Anat & Genet, Oxford, England Univ Oxford, Dept Physiol Anat & Genet, Oxford, England
[3]
Therapeutic efficacy of cardiosphere-derived cells in a transgenic mouse model of non-ischaemic dilated cardiomyopathy
[J].
Aminzadeh, Mohammad A.
;
Tseliou, Eleni
;
Sun, Baiming
;
Cheng, Ke
;
Malliaras, Konstantinos
;
Makkar, Raj R.
;
Marban, Eduardo
.
EUROPEAN HEART JOURNAL,
2015, 36 (12)
:751-762

Aminzadeh, Mohammad A.
论文数: 0 引用数: 0
h-index: 0
机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Tseliou, Eleni
论文数: 0 引用数: 0
h-index: 0
机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Sun, Baiming
论文数: 0 引用数: 0
h-index: 0
机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Cheng, Ke
论文数: 0 引用数: 0
h-index: 0
机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Malliaras, Konstantinos
论文数: 0 引用数: 0
h-index: 0
机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Makkar, Raj R.
论文数: 0 引用数: 0
h-index: 0
机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Marban, Eduardo
论文数: 0 引用数: 0
h-index: 0
机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA
[4]
Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy
[J].
Bang, Claudia
;
Batkai, Sandor
;
Dangwal, Seema
;
Gupta, Shashi Kumar
;
Foinquinos, Ariana
;
Holzmann, Angelika
;
Just, Annette
;
Remke, Janet
;
Zimmer, Karina
;
Zeug, Andre
;
Ponimaskin, Evgeni
;
Schmiedl, Andreas
;
Yin, Xiaoke
;
Mayr, Manuel
;
Halder, Rashi
;
Fischer, Andre
;
Engelhardt, Stefan
;
Wei, Yuanyuan
;
Schober, Andreas
;
Fiedler, Jan
;
Thum, Thomas
.
JOURNAL OF CLINICAL INVESTIGATION,
2014, 124 (05)
:2136-2146

Bang, Claudia
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Batkai, Sandor
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Dangwal, Seema
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Gupta, Shashi Kumar
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Foinquinos, Ariana
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Holzmann, Angelika
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Just, Annette
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Remke, Janet
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Zimmer, Karina
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Zeug, Andre
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Inst Neurophysiol, D-30625 Hannover, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Ponimaskin, Evgeni
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Inst Neurophysiol, D-30625 Hannover, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Schmiedl, Andreas
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Inst Funct & Appl Anat, D-30625 Hannover, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Yin, Xiaoke
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Cardiovasc Div, London, England Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Mayr, Manuel
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Cardiovasc Div, London, England Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Halder, Rashi
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr, German Ctr Neurodegenerat Dis, Gottingen, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Fischer, Andre
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr, German Ctr Neurodegenerat Dis, Gottingen, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Engelhardt, Stefan
论文数: 0 引用数: 0
h-index: 0
机构:
Tech Univ Munich, Inst Pharmacol & Toxicol, D-80290 Munich, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Wei, Yuanyuan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Munich, Inst Cardiovasc Prevent, Munich, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Schober, Andreas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Munich, Inst Cardiovasc Prevent, Munich, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Fiedler, Jan
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany

Thum, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany
Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England
Hannover Med Sch, REBIRTH Excellence Cluster, D-30625 Hannover, Germany Hannover Med Sch, Integrated Res & Treatment Ctr Transplantat IFB T, IMTTS, D-30625 Hannover, Germany
[5]
Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction
[J].
Barile, Lucio
;
Lionetti, Vincenzo
;
Cervio, Elisabetta
;
Matteucci, Marco
;
Gherghiceanu, Mihaela
;
Popescu, Laurentiu M.
;
Torre, Tiziano
;
Siclari, Francesco
;
Moccetti, Tiziano
;
Vassalli, Giuseppe
.
CARDIOVASCULAR RESEARCH,
2014, 103 (04)
:530-541

Barile, Lucio
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn Cardioctr Ticino, Dept Cardiol, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland
Fdn Cardioctr Ticino, Dept Heart Surg, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland Fdn Cardioctr Ticino, Dept Cardiol, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland

Lionetti, Vincenzo
论文数: 0 引用数: 0
h-index: 0
机构:
Scuola Super Sant Anna, Inst Life Sci, Lab Med Sci, Pisa, Italy Fdn Cardioctr Ticino, Dept Cardiol, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland

Cervio, Elisabetta
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn Cardioctr Ticino, Dept Cardiol, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland
Fdn Cardioctr Ticino, Dept Heart Surg, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland Fdn Cardioctr Ticino, Dept Cardiol, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland

Matteucci, Marco
论文数: 0 引用数: 0
h-index: 0
机构:
Scuola Super Sant Anna, Inst Life Sci, Lab Med Sci, Pisa, Italy Fdn Cardioctr Ticino, Dept Cardiol, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland

Gherghiceanu, Mihaela
论文数: 0 引用数: 0
h-index: 0
机构:
Victor Babes Natl Inst Pathol, Bucharest, Romania Fdn Cardioctr Ticino, Dept Cardiol, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland

Popescu, Laurentiu M.
论文数: 0 引用数: 0
h-index: 0
机构:
Victor Babes Natl Inst Pathol, Bucharest, Romania Fdn Cardioctr Ticino, Dept Cardiol, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland

Torre, Tiziano
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn Cardioctr Ticino, Dept Cardiol, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland
Fdn Cardioctr Ticino, Dept Heart Surg, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland Fdn Cardioctr Ticino, Dept Cardiol, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland

Siclari, Francesco
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn Cardioctr Ticino, Dept Cardiol, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland
Fdn Cardioctr Ticino, Dept Heart Surg, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland Fdn Cardioctr Ticino, Dept Cardiol, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland

Moccetti, Tiziano
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn Cardioctr Ticino, Dept Cardiol, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland
Fdn Cardioctr Ticino, Dept Heart Surg, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland Fdn Cardioctr Ticino, Dept Cardiol, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland

Vassalli, Giuseppe
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn Cardioctr Ticino, Dept Cardiol, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland
Fdn Cardioctr Ticino, Dept Heart Surg, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland
CHU Vaudois, Dept Cardiol, CH-1011 Lausanne, Switzerland Fdn Cardioctr Ticino, Dept Cardiol, Lab Mol & Cellular Cardiol, CH-6900 Lugano, Switzerland
[6]
Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct Reprogramming
[J].
Burridge, Paul W.
;
Keller, Gordon
;
Gold, Joseph D.
;
Wu, Joseph C.
.
CELL STEM CELL,
2012, 10 (01)
:16-28

Burridge, Paul W.
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Dept Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
Stanford Univ, Sch Med, Cardiovasc Inst, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

Keller, Gordon
论文数: 0 引用数: 0
h-index: 0
机构:
MaRS Ctr, Univ Hlth Network, McEwen Ctr Regenerat Med, Toronto, ON MG5 1L7, Canada Stanford Univ, Sch Med, Dept Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

Gold, Joseph D.
论文数: 0 引用数: 0
h-index: 0
机构:
Geron Corp, Neurobiol & Cell Therapies Res, Menlo Pk, CA 94025 USA Stanford Univ, Sch Med, Dept Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

Wu, Joseph C.
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Dept Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
Stanford Univ, Sch Med, Cardiovasc Inst, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
[7]
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
[J].
Chendrimada, TP
;
Gregory, RI
;
Kumaraswamy, E
;
Norman, J
;
Cooch, N
;
Nishikura, K
;
Shiekhattar, R
.
NATURE,
2005, 436 (7051)
:740-744

Chendrimada, TP
论文数: 0 引用数: 0
h-index: 0
机构:
Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

Gregory, RI
论文数: 0 引用数: 0
h-index: 0
机构:
Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

Kumaraswamy, E
论文数: 0 引用数: 0
h-index: 0
机构:
Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

Norman, J
论文数: 0 引用数: 0
h-index: 0
机构:
Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

Cooch, N
论文数: 0 引用数: 0
h-index: 0
机构:
Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

Nishikura, K
论文数: 0 引用数: 0
h-index: 0
机构:
Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

Shiekhattar, R
论文数: 0 引用数: 0
h-index: 0
机构:
Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA
[8]
Relative Roles of Direct Regeneration Versus Paracrine Effects of Human Cardiosphere-Derived Cells Transplanted Into Infarcted Mice
[J].
Chimenti, Isotta
;
Smith, Rachel Ruckdeschel
;
Li, Tao-Sheng
;
Gerstenblith, Gary
;
Messina, Elisa
;
Giacomello, Alessandro
;
Marban, Eduardo
.
CIRCULATION RESEARCH,
2010, 106 (05)
:971-U304

Chimenti, Isotta
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Expt Med, Inst Pasteur, Cenci Bolognetti Fdn, I-00185 Rome, Italy Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Smith, Rachel Ruckdeschel
论文数: 0 引用数: 0
h-index: 0
机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Li, Tao-Sheng
论文数: 0 引用数: 0
h-index: 0
机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Gerstenblith, Gary
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Div Cardiol, Baltimore, MD USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

论文数: 引用数:
h-index:
机构:

Giacomello, Alessandro
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Expt Med, Inst Pasteur, Cenci Bolognetti Fdn, I-00185 Rome, Italy Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

Marban, Eduardo
论文数: 0 引用数: 0
h-index: 0
机构:
Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA
[9]
Shedding microvesicles: artefacts no more
[J].
Cocucci, Emanuele
;
Racchetti, Gabriella
;
Meldolesi, Jacopo
.
TRENDS IN CELL BIOLOGY,
2009, 19 (02)
:43-51

Cocucci, Emanuele
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vita Salute San Raffaele, Ctr Excellence Cell Dev, I-20132 Milan, Italy Univ Vita Salute San Raffaele, Ctr Excellence Cell Dev, I-20132 Milan, Italy

Racchetti, Gabriella
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Univ Vita Salute San Raffaele, San Raffaele Sci Inst, I-20132 Milan, Italy Univ Vita Salute San Raffaele, Ctr Excellence Cell Dev, I-20132 Milan, Italy

Meldolesi, Jacopo
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Univ Vita Salute San Raffaele, Ctr Excellence Cell Dev, I-20132 Milan, Italy
Univ Vita Salute San Raffaele, San Raffaele Sci Inst, I-20132 Milan, Italy
Univ Vita Salute San Raffaele, Natl Inst Neurosci, I-20132 Milan, Italy
Univ Vita Salute San Raffaele, IIT Network, I-20132 Milan, Italy
Univ Vita Salute San Raffaele, Res Unit Mol Neurosci, I-20132 Milan, Italy Univ Vita Salute San Raffaele, Ctr Excellence Cell Dev, I-20132 Milan, Italy
[10]
Extracellular vesicles: biology and emerging therapeutic opportunities
[J].
EL Andaloussi, Samir
;
Maeger, Imre
;
Breakefield, Xandra O.
;
Wood, Matthew J. A.
.
NATURE REVIEWS DRUG DISCOVERY,
2013, 12 (05)
:348-358

EL Andaloussi, Samir
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Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QX, England
Karolinska Inst, Dept Lab Med, SE-14186 Solna, Sweden Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QX, England

Maeger, Imre
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Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QX, England
Univ Tartu, Inst Technol, EE-50411 Tartu, Estonia Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QX, England

Breakefield, Xandra O.
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Massachusetts Gen Hosp, Neurogenet Unit, Charlestown, MA USA Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QX, England

Wood, Matthew J. A.
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Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QX, England Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QX, England