COVID-19-Associated Hepatitis Complicating Recent Living Donor Liver Transplantation

被引：53

作者：

Lagana, Stephen M. ^{[1
]}

De Michele, Simona ^{[1
]}

Lee, Michael J. ^{[1
]}

Emond, Jean C. ^{[2
]}

Griesemer, Adam D. ^{[2
]}

Tulin-Silver, Sheryl A. ^{[3
]}

Verna, Elizabeth C. ^{[4
]}

Martinez, Mercedes ^{[5
]}

Lefkowitch, Jay H. ^{[1
]}

机构：

[1] Columbia Univ, Med Ctr, Dept Pathol & Cell Biol, 630 West 168th St,VC14-209, New York, NY 10032 USA

[2] Columbia Univ, Med Ctr, Dept Surg, New York, NY 10032 USA

[3] Columbia Univ, Med Ctr, Dept Radiol, New York, NY 10032 USA

[4] Columbia Univ, Med Ctr, Dept Med Digest & Liver Dis, New York, NY 10032 USA

[5] Columbia Univ, Med Ctr, Dept Pediat, New York, NY 10032 USA

来源：

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | 2020年 / 144卷 / 08期

关键词：

CENTRAL VENULITIS; CORONAVIRUS;

D O I：

10.5858/arpa.2020-0186-SA

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

We present a case of COVID-19 hepatitis in a living donor liver allograft recipient whose donor subsequently tested positive for COVID-19. The patient is a female infant with biliary atresia (failed Kasai procedure). She recovered well, with improving liver function tests for 4 days. On postoperative day 4 the patient developed respiratory distress and fever. COVID-19 testing (polymerase chain reaction) was positive. Liver function test results increased approximately 5-fold. Liver biopsy showed moderate acute hepatitis with prominent clusters of apoptotic hepatocytes and associated cellular debris. Lobular lymphohistiocytic inflammation was noted. Typical portal features of mild to moderate acute cellular rejection were also noted.

引用

页码：929 / 932

页数：4

共 10 条

[1] Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection - clinicopathological and ultrastructural study [J].