Reactivity of the 1,3-β-D-glucan assay during bacteraemia: limited evidence from a prospective study

被引：13

作者：

Racil, Zdenek ^{[1
,2
,4
]}

Kocmanova, Iva ^{[3
]}

Toskova, Martina ^{[1
,2
]}

Winterova, Jana ^{[1
,2
]}

Lengerova, Martina ^{[1
,2
]}

Timilsina, Shira ^{[1
,2
]}

Mayer, Jiri ^{[1
,2
,4
]}

机构：

[1] Masaryk Univ, Dept Internal Med Hematol & Oncol, Brno, Czech Republic

[2] Univ Hosp Brno, Brno 62500, Czech Republic

[3] Univ Hosp Brno, Dept Microbiol, Brno 62500, Czech Republic

[4] Masaryk Univ, CEITEC Cent European Inst Technol, Brno, Czech Republic

来源：

MYCOSES | 2013年 / 56卷 / 02期

关键词：

1; 3--D-glucan; bacteraemia; haematological malignancy; INVASIVE FUNGAL-INFECTIONS; BETA-D-GLUCAN; EARLY-DIAGNOSIS; ASPERGILLOSIS; COMPONENTS; SERUM;

D O I：

10.1111/j.1439-0507.2012.02210.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

There are discrepancies in the retrospective studies published in literature of whether or not bacteraemia could lead to false positivity of 1,3--D (BG) glucan assay. We performed, for the first time, a prospective study evaluating the role of bacterial bloodstream infection to the reactivity of BG assay. Twenty-six episodes of bacteraemia that occurred in high-risk haematological patients were included in our study. Consecutive BG levels >80pgml1 were required for test positivity. Only 2 of 26 patients were BG positive both with IFDs. Thus, we prospectively did not prove bacteraemia as the source of cross reactivity of BG assay in haematological patients.

引用

页码：101 / 104

页数：4

共 25 条

[1] Reactivity of (1→3)-β-d-glucan assay in bacterial bloodstream infections [J].

Albert, O. ;

Toubas, D. ;

Strady, C. ;

Cousson, J. ;

Delmas, C. ;

Vernet, V. ;

Villena, I. .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2011, 30 (11) :1453-1460

[2] Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group [J].

De Pauw, Ben ;

Walsh, Thomas J. ;

Donnelly, J. Peter ;

Stevens, David A. ;

Edwards, John E. ;

Calandra, Thierry ;

Pappas, Peter G. ;

Maertens, Johan ;

Lortholary, Olivier ;

Kauffman, Carol A. ;

Denning, David W. ;

Patterson, Thomas F. ;

Maschmeyer, Georg ;

Bille, Jacques ;

Dismukes, William E. ;

Herbrecht, Raoul ;

Hope, William W. ;

Kibbler, Christopher C. ;

Kullberg, Bart Jan ;

Marr, Kieren A. ;

Munoz, Patricia ;

Odds, Frank C. ;

Perfect, John R. ;

Restrepo, Angela ;

Ruhnke, Markus ;

Segal, Brahm H. ;

Sobel, Jack D. ;

Sorrell, Tania C. ;

Viscoli, Claudio ;

Wingard, John R. ;

Zaoutis, Theoklis ;

Bennett, John E. .

CLINICAL INFECTIOUS DISEASES, 2008, 46 (12) :1813-1821

[3] Serum glucan levels are not specific for presence of fungal infections in intensive care unit patients [J].

Digby, J ;

Kalbfleisch, J ;

Glenn, A ;

Larsen, A ;

Browder, W ;

Williams, D .

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2003, 10 (05) :882-885

[4] Assessment of the clinical utility of serial β-D-glucan concentrations in patients with persistent neutropenic fever [J].

Ellis, Michael ;

Al-Ramadi, Basel ;

Finkelman, Malcolm ;

Hedstrom, Ulla ;

Kristensen, Jorgen ;

Ali-Zadeh, Hussein ;

Klingspor, Lena .

JOURNAL OF MEDICAL MICROBIOLOGY, 2008, 57 (03) :287-295

[5] Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: A multi-institutional study [J].

Garey, Kevin W. ;

Rege, Milind ;

Pai, Manjunath P. ;

Mingo, Dana E. ;

Suda, Katie J. ;

Turpin, Robin S. ;

Bearden, David T. .

CLINICAL INFECTIOUS DISEASES, 2006, 43 (01) :25-31

[6] Measurement of (1-3)-β-D-Glucan Derived from Different Gauze Types [J].

Kanamori, Hajime ;

Kanemitsu, Keiji ;

Miyasaka, Tomomitsu ;

Ameku, Koken ;

Endo, Shiro ;

Aoyagi, Tetsuji ;

Inden, Ken ;

Hatta, Masumitsu ;

Yamamoto, Natsuo ;

Kunishima, Hiroyuki ;

Yano, Hisakazu ;

Kaku, Koki ;

Hirakata, Yoichi ;

Kaku, Mitsuo .

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 217 (02) :117-121

[7] Influence of various hemodialysis membranes on the plasma (1→3)-β-D-glucan level [J].

Kanda, H ;

Kubo, K ;

Hamasaki, K ;

Kanda, Y ;

Nakao, A ;

Kitamura, T ;

Fujita, T ;

Yamamoto, K ;

Mimura, T .

KIDNEY INTERNATIONAL, 2001, 60 (01) :319-323

[8] Current status of fungal cell wall components in the immunodiagnostics of invasive fungal infections in humans:: galactomannan, mannan and (1→3)-β-D-glucan antigens [J].

Kedzierska, A. ;

Kochan, P. ;

Pietrzyk, A. ;

Kedzierska, J. .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2007, 26 (11) :755-766

[9]

Kedzierska Anna, 2007, Polish Journal of Microbiology, V56, P3

[10] CLINICAL AND EXPERIMENTAL STUDIES OF THE LIMULUS TEST AFTER DIGESTIVE SURGERY [J].

KIMURA, Y ;

NAKAO, A ;

TAMURA, E ;

TANAKA, S ;

TAKAGI, H .

SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 1995, 25 (09) :790-794

← 1 2 3 →