Fruit and Vegetable Intake and Risk of Breast Cancer by Hormone Receptor Status

被引：132

作者：

Jung, Seungyoun ^{[1
,2
,11
,12
]}

Spiegelman, Donna ^{[2
,3
]}

Baglietto, Laura ^{[4
,5
]}

Bernstein, Leslie ^{[6
,7
]}

Boggs, Deborah A. ^{[8
]}

van den Brandt, Piet A. ^{[9
]}

Buring, Julie E. ^{[2
,10
]}

Cerhan, James R. ^{[14
]}

Gaudet, Mia M. ^{[15
]}

Giles, Graham G. ^{[4
,5
]}

Goodman, Gary ^{[16
]}

Hakansson, Niclas ^{[17
]}

Hankinson, Susan E. ^{[2
,11
,13
]}

Helzlsouer, Kathy ^{[19
,20
]}

Horn-Ross, Pamela L. ^{[21
]}

Inoue, Manami ^{[22
]}

Krogh, Vittorio ^{[23
]}

Lof, Marie ^{[24
]}

McCullough, Marjorie L. ^{[15
]}

Miller, Anthony B. ^{[25
]}

Neuhouser, Marian L. ^{[16
]}

Palmer, Julie R. ^{[8
]}

Park, Yikyung ^{[26
]}

Robien, Kim ^{[27
,28
]}

Rohan, Thomas E. ^{[29
]}

Scarmo, Stephanie ^{[30
]}

Schairer, Catherine ^{[26
]}

Schouten, Leo J. ^{[9
]}

Shikany, James M. ^{[31
]}

Sieri, Sabina ^{[23
]}

Tsugane, Schoichiro ^{[22
]}

Visvanathan, Kala ^{[20
]}

Weiderpass, Elisabete ^{[18
,32
,33
,34
]}

Willett, Walter C. ^{[1
,2
,11
]}

Wolk, Alicja ^{[17
]}

Zeleniuch-Jacquotte, Anne ^{[30
]}

Zhang, Shumin M. ^{[10
]}

Zhang, Xuehong ^{[11
]}

Ziegler, Regina G. ^{[26
]}

Smith-Warner, Stephanie A. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[4] Canc Council Victoria, Canc Epidemiol Ctr, Carlton, Vic, Australia

[5] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia

[6] City Hope Natl Med Ctr, Beckman Res Inst, Div Canc Etiol, Dept Populat Sci, Duarte, CA 91010 USA

[7] City Hope Natl Med Ctr, Duarte, CA 91010 USA

[8] Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA

[9] Maastricht Univ, GROW Sch Oncol & Dev Biol, Dept Epidemiol, Maastricht, Netherlands

[10] Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA

[11] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA

[12] Harvard Univ, Sch Med, Boston, MA 02115 USA

[13] Univ Massachussetts, Div Biostat & Epidemiol, Amherst, MA USA

[14] Mayo Clin, Coll Med, Dept Hlth Sci Res, Rochester, MN USA

[15] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[16] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA

[17] Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, S-10401 Stockholm, Sweden

[18] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[19] St Johns Mercy Med Ctr, Weinberg Ctr Womens Hlth & Med, Prevent & Res Ctr, Baltimore, MD USA

[20] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[21] Canc Prevent Inst Calif, Fremont, CA USA

[22] Natl Canc Ctr, Res Ctr Canc Prevent & Screening, Epidemiol & Prevent Div, Tokyo 104, Japan

[23] Fdn IRCCS Ist Nazl Tumori Milano, Nutr Epidemiol Unit, Milan, Italy

[24] Linkoping Univ, Dept Clin & Expt Med, S-58183 Linkoping, Sweden

[25] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[26] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA

[27] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[28] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA

[29] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA

[30] NYU, Dept Environm Med, Sch Med, New York, NY 10016 USA

[31] Univ Alabama Birmingham, Sch Med, Div Prevent Med, Birmingham, AL USA

[32] Univ Tromso, Inst Community Med, Tromso, Norway

[33] Canc Registry Norway, Dept Etiol Res, Oslo, Norway

[34] Folkhalsan Res Ctr, Dept Genet Epidemiol, Helsinki, Finland

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2013年 / 105卷 / 03期

关键词：

ESTROGEN-RECEPTOR; DIETARY PATTERNS; POOLED ANALYSIS; WOMENS HEALTH; PROSPECTIVE COHORT; ANTIOXIDANT INTAKE; VITAMIN-C; QUESTIONNAIRE; VALIDATION; PREVENTION;

D O I：

10.1093/jnci/djs635

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Estrogen receptornegative (ER) breast cancer has few known or modifiable risk factors. Because ER tumors account for only 15% to 20% of breast cancers, large pooled analyses are necessary to evaluate precisely the suspected inverse association between fruit and vegetable intake and risk of ER breast cancer. Among 993 466 women followed for 11 to 20 years in 20 cohort studies, we documented 19 869 estrogen receptor positive (ER) and 4821 ER breast cancers. We calculated study-specific multivariable relative risks (RRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression analyses and then combined them using a random-effects model. All statistical tests were two-sided. Total fruit and vegetable intake was statistically significantly inversely associated with risk of ER breast cancer but not with risk of breast cancer overall or of ER tumors. The inverse association for ER tumors was observed primarily for vegetable consumption. The pooled relative risks comparing the highest vs lowest quintile of total vegetable consumption were 0.82 (95% CI 0.74 to 0.90) for ER breast cancer and 1.04 (95% CI 0.97 to 1.11) for ER breast cancer (Pcommon-effects by ER status < .001). Total fruit consumption was non-statistically significantly associated with risk of ER breast cancer (pooled multivariable RR comparing the highest vs lowest quintile 0.94, 95% CI 0.85 to 1.04). We observed no association between total fruit and vegetable intake and risk of overall breast cancer. However, vegetable consumption was inversely associated with risk of ER breast cancer in our large pooled analyses.

引用

页码：219 / 236

页数：18

共 88 条

[1] Cyclin D1 expression is associated with poor prognostic features in estrogen receptor positive breast cancer [J].