Vault particles: a new generation of delivery nanodevices

被引：18

作者：

Casanas, Arnau ^{[1
]}

Guerra, Pablo ^{[1
]}

Fita, Ignasi ^{[1
]}

Verdaguer, Nuria ^{[1
]}

机构：

[1] CSIC, Inst Biol Mol Barcelona, E-08028 Barcelona, Spain

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2012年 / 23卷 / 06期

关键词：

RIBONUCLEOPROTEIN-PARTICLES; DRUG-DELIVERY; SMALL RNA; PROTEIN; NANOPARTICLES; NANOCAPSULES; POLYMERASE; RESOLUTION; IMMUNITY; CONTAIN;

D O I：

10.1016/j.copbio.2012.05.004

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Vault particles possess many attributes that can be exploited in nanobiotechnology, particularly in the creation of drug delivery nanodevices. These include self-assembly, 100 nm size range, a dynamic structure that may be controlled for manipulation of drug release kinetics and natural presence in humans ensuring biocompatibility. The flexibility and the adaptability of this system have been greatly enhanced by the emerging atomic-level information and improved comprehension of vault structure and dynamics. It seems likely that this information will allow their specific tailoring to the individual requirements of each drug and target tissue. These properties provide vaults with an enormous potential as a versatile delivery platform.

引用

页码：972 / 977

页数：6

共 33 条

[1] Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell [J].

Abbondanza, C ;

Rossi, V ;

Roscigno, A ;

Gallo, L ;

Belsito, A ;

Piluso, G ;

Medici, N ;

Nigro, V ;

Molinari, AM ;

Moncharmont, B ;

Puca, GA .

JOURNAL OF CELL BIOLOGY, 1998, 141 (06) :1301-1310

[2] Vaults and the major vault protein: Novel roles in signal pathway regulation and immunity [J].

Berger, W. ;

Steiner, E. ;

Grusch, M. ;

Elbling, L. ;

Micksche, M. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2009, 66 (01) :43-61

[3] Nanoparticles in cancer therapy and diagnosis [J].

Brigger, I ;

Dubernet, C ;

Couvreur, P .

ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (05) :631-651

[4] Vaults Engineered for Hydrophobic Drug Delivery [J].

Buehler, Daniel C. ;

Toso, Daniel B. ;

Kickhoefer, Valerie A. ;

Zhou, Z. Hong ;

Rome, Leonard H. .

SMALL, 2011, 7 (10) :1432-1439

[5] A Vault Nanoparticle Vaccine Induces Protective Mucosal Immunity [J].

Champion, Cheryl I. ;

Kickhoefer, Valerie A. ;

Liu, Guangchao ;

Moniz, Raymond J. ;

Freed, Amanda S. ;

Bergmann, Liisa L. ;

Vaccari, Dana ;

Raval-Fernandes, Sujna ;

Chan, Ann M. ;

Rome, Leonard H. ;

Kelly, Kathleen A. .

PLOS ONE, 2009, 4 (04)

[6] Structural Stability of Vault Particles [J].

Esfandiary, Reza ;

Kickhoefer, Valerie A. ;

Rome, Leonard H. ;

Joshi, Sangeeta B. ;

Middaugh, C. Russell .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 98 (04) :1376-1386

[7] Vault nanocapsule dissociation into halves triggered at low pH [J].

Goldsmith, Lisa E. ;

Yu, Marcella ;

Rome, Leonard H. ;

Monbouquette, Harold G. .

BIOCHEMISTRY, 2007, 46 (10) :2865-2875

[8] Utilization of a Protein "Shuttle" To Load Vault Nanocapsules with Gold Probes and Proteins [J].

Goldsmith, Lisa E. ;

Pupols, Melody ;

Kickhoefer, Valerie A. ;

Rome, Leonard H. ;

Monbouquette, Harold G. .

ACS NANO, 2009, 3 (10) :3175-3183

[9] Depletion of major vault protein increases doxorubicin sensitivity and nuclear accumulation and disrupts its sequestration in lysosomes [J].

Herlevsen, Mikael ;

Oxford, Gary ;

Owens, Charles R. ;

Conaway, Mark ;

Theodorescu, Dan .

MOLECULAR CANCER THERAPEUTICS, 2007, 6 (06) :1804-1813

[10] Novel CCL21-Vault Nanocapsule Intratumoral Delivery Inhibits Lung Cancer Growth [J].

Kar, Upendra K. ;

Srivastava, Minu K. ;

Andersson, Asa ;

Baratelli, Felicita ;

Huang, Min ;

Kickhoefer, Valerie A. ;

Dubinett, Steven M. ;

Rome, Leonard H. ;

Sharma, Sherven .

PLOS ONE, 2011, 6 (05)

← 1 2 3 4 →