Sargaquinoic acid and sargahydroquinoic acid from Sargassum yezoense stimulate adipocyte differentiation through PPARα/γ activation in 3T3-L1 cells

被引：60

作者：

Kim, Su-Nam ^{[2
]}

Choi, Hye Young ^{[1
]}

Lee, Woojung ^{[2
]}

Park, Gab Man ^{[1
]}

Shin, Woon Seob ^{[1
]}

Kim, Yong Kee ^{[1
]}

机构：

[1] Kwandong Univ, Coll Med, Kangnung 210701, South Korea

[2] KIST Gangneung Inst, Kangnung 210340, South Korea

来源：

FEBS LETTERS | 2008年 / 582卷 / 23-24期

关键词：

PPAR alpha/gamma agonist; Sargaquinoic acid; Sargahydroquinoic acid; Sargassum yezoense;

D O I：

10.1016/j.febslet.2008.09.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We screened active compounds from natural marine products able to increase PPAR alpha/gamma transcriptional activity. Sargaquinoic acid (SQA) and sargahydroquinoic acid (SHQA) from Sargassum yezoense were identified as novel PPAR alpha/gamma dual agonists. The binding affinity of SQA with PPAR gamma was higher than that of the specific PPAR gamma agonist troglitazone, leading to an activation of PPAR gamma transcriptional activity. In parallel, treatment of 3T3-L1 cells with SQA and SHQA led to an increase in adipocyte differentiation and increased expression of adipogenic marker genes such as aP2, PPAR gamma, resistin, adiponectin, C/EBP alpha and Glut4. Collectively, our data suggest that SQA and SHQA are novel PPAR alpha/gamma dual agonists and may be beneficial for reducing insulin resistance through regulation of adipogenesis.

引用

页码：3465 / 3472

页数：8

共 21 条

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