Asthma Drugs and the Risk of Congenital Anomalies

被引：23

作者：

Vasilakis-Scaramozza, Catherine ^{[1
]}

Aschengrau, Ann ^{[1
]}

Cabral, Howard J. ^{[1
]}

Jick, Susan S. ^{[2
]}

机构：

[1] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[2] Boston Univ, Sch Med, Boston Collaborat Drug Surveillance Program, Lexington, MA 02421 USA

来源：

PHARMACOTHERAPY | 2013年 / 33卷 / 04期

关键词：

asthma; congenital anomalies; prevalence rates; relative risk; MATERNAL ASTHMA; MEDICATION USE; PREGNANCY; CORTICOSTEROIDS;

D O I：

10.1002/phar.1213

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Study Objective To estimate the prevalence of congenital anomalies between the offspring of women exposed and unexposed to asthma drugs during early pregnancy. Design Matched cohort study. Database The United Kingdom's General Practice Research Database. Patients Women exposed to asthma drugs during early pregnancy and a sample of matched unexposed pregnant women. Measurements and Main Results The prevalence of any anomaly among unexposed and exposed women was 27.8 (95% confidence interval [CI] 25.430.6)/1000 pregnancies and 31.3 (95% CI 27.735.5)/1000 pregnancies, respectively (relative risk [RR] 1.1 95% CI 1.01.3). Conclusion Our findings suggest that asthma drugs, overall, do not increase the risk of congenital anomalies in the offspring when taken during the first trimester of pregnancy.

引用

页码：363 / 368

页数：6

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