What is the key environmental trigger in type 1 diabetes - Is it viruses, or wheat gluten, or both?

被引：21

作者：

Barbeau, William E. ^{[1
]}

机构：

[1] Virginia Tech, Dept Human Nutr Foods & Exercise, Blacksburg, VA 24061 USA

来源：

AUTOIMMUNITY REVIEWS | 2012年 / 12卷 / 02期

关键词：

Type; 1; diabetes; Viruses; Wheat gluten; Environmental trigger; INCREASED INTESTINAL PERMEABILITY; PANCREATIC BETA-CELLS; CELIAC-DISEASE; NOD MICE; ORAL TOLERANCE; T-CELLS; POPULATION-DENSITY; BB RATS; MELLITUS; RISK;

D O I：

10.1016/j.autrev.2012.05.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Prevention and treatment of type 1 diabetes is hampered by the fact that the key environmental trigger(s) of the disease is still unknown. Much of the data on this subject points to two possibilities, viruses and wheat gluten. Viruses appear to be involved as an etiological agent in some cases of type I diabetes, particularly in fulminant type 1 diabetes. Further analysis of the data suggests that viruses are not the sole trigger of type I diabetes in humans, and that wheat gluten may play a role in initiating the disease. Viruses may be the key environmental trigger in some cases of type 1 diabetes, and wheat gluten in others. Conceivably, some cases of type 1 diabetes might be caused by viruses and wheat gluten acting together as disease triggers. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：295 / 299

页数：5

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