Phenolic glycosides from Curculigo orchioides Gaertn.

被引：24

作者：

Wang, Zhen-Hui ^{[1
]}

Huang, Jian ^{[1
]}

Ma, Xiao-Ci ^{[2
]}

Li, Guo-Yu ^{[3
]}

Ma, Yue-Ping ^{[1
]}

Li, Ning ^{[1
]}

Wang, Jin-Hui ^{[1
,3
,4
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med 49, Shenyang 110016, Peoples R China

[2] Dalian Med Univ, Coll Pharm, Dalian 116044, Peoples R China

[3] Shihezi Univ, Sch Pharm, Shihezi 832002, Peoples R China

[4] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China

来源：

FITOTERAPIA | 2013年 / 86卷

关键词：

Curculigo orchioides Gaertn; Phenolic glycosides; NMR; Antiosteoporotic activity;

D O I：

10.1016/j.fitote.2013.01.008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new chlorophenolic glucosides, curculigine E (1), curculigine F (2), curculigine G (3), curculigine H (5), curculigine I (6) and one new phenolic glycoside, orcinoside H (4), together with eight known phenolic glycosides (7-14) were isolated from the Curculigo orchioides Gaertn. Their structures were established by spectroscopic techniques (IR, UV, MS, 1D and 2D NMR). The isolated phenolic glycosides were evaluated for antiosteoporotic activity against MC3T3-E1 cell line using MTT assays. Compounds 1, 2, 3, and 5 showed moderate antiosteoporotic activity with the proliferation rate of 101-14.1%. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：64 / 69

页数：6

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