Effects of treadmill exercise on memory and c-Fos expression in the hippocampus of the rats with intracerebroventricular injection of streptozotocin

被引：69

作者：

Jee, Yong-Seok ^{[2
]}

Ko, Il-Gyu ^{[1
,2
]}

Sung, Yun-Hee ^{[1
]}

Lee, Jin-Woo ^{[1
]}

Kim, Young-Sick ^{[1
]}

Kim, Sung-Eun ^{[1
]}

Kim, Bo-Kyun ^{[1
]}

Seo, Jin-Hee ^{[1
]}

Shin, Mal-Soon ^{[1
]}

Lee, Hee-Hyuk ^{[3
]}

Cho, Han-Jin ^{[4
]}

Kim, Chang-Ju ^{[1
]}

机构：

[1] Kyung Hee Univ, Coll Med, Dept Physiol, Seoul 130701, South Korea

[2] Han Seo Univ, Coll Sci, Dept Leisure Sports, Seosam Si 356706, Chungcheongnam, South Korea

[3] Han Nam Univ, Coll Nat Sci, Dept Sports Sci, Taejon 306791, South Korea

[4] Kyung Hee Univ, Coll Med, Dept Emergency Med, Seoul 130701, South Korea

来源：

NEUROSCIENCE LETTERS | 2008年 / 443卷 / 03期

关键词：

Alzheimer' disease; streptozotocin; treadmill exercise; c-Fos; long-term memory; hippocampus;

D O I：

10.1016/j.neulet.2008.07.078

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease is a progressive neurodegenerative disease clinically characterized by dementia and neurobehavioral deterioration. Hippocampal neurons are vulnerable to injury induced by Alzheimer's disease. The immediate early gene c-Fos has been used as a marker of neuronal activity. In the present study, we investigated the effects of treadmill exercise on long-term memory capacity and c-Fos expression in the hippocampus of rats with Alzheimer's disease. The rat model of Alzheimer's disease used in the present study was induced by the intracerebroventricular (ICV) injection of streptozotocin (STZ) using a stereotaxic instrument. The rats in the exercise group were forced to run on a treadmill for 30 min once daily for 14 consecutive days starting at 3 days after the ICV injection of STZ. The results of the present study showed that ICV injection of STZ impaired long-term memory capacity and decreased the number of c-Fos-positive cells in several regions of the rat hippocampus. However, treadmill exercise alleviated long-term memory deficits and enhanced c-Fos expression in the rats with ICV injection of STZ. The results of the present study showed that treadmill exercise could be a useful strategy for treating several neurodegenerative diseases. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：188 / 192

页数：5

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