Nutrition and Gastrointestinal Microbiota, Microbial-Derived Secondary Bile Acids, and Cardiovascular Disease

被引:29
|
作者
Rodriguez-Morato, Jose [1 ,2 ,3 ]
Matthan, Nirupa R. [4 ]
机构
[1] Hosp del Mar, IMIM, Integrat Pharmacol & Syst Neurosci Res Grp, Med Res Inst, Doctor Aiguader 88, Barcelona 08003, Spain
[2] Inst Salud Carlos III, Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid 28029, Spain
[3] Univ Pompeu Fabra CEXS UPF, Dept Expt & Hlth Sci, Dr Aiguader 80, Barcelona 08003, Spain
[4] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Cardiovasc Nutr Lab, 711 Washington St, Boston, MA 02111 USA
基金
欧盟地平线“2020”;
关键词
Diet; Bile acids; Gut microbiota; Cardiometabolic risk factors; Cardiovascular disease; Metabolism; GUT MICROBIOTA; INTESTINAL MICROBIOTA; NUCLEAR RECEPTOR; HEALTHY-ADULTS; RISK-FACTORS; FOLLOW-UP; HIGH-FAT; CHOLESTEROL; METABOLISM; SERUM;
D O I
10.1007/s11883-020-00863-7
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Purpose of Review The goal is to review the connection between gut microbiota and cardiovascular disease, with specific emphasis on bile acids, and the influence of diet in modulating this relationship. Recent Findings Bile acids exert a much broader range of biological functions than initially recognized, including regulation of cardiovascular function through direct and indirect mechanisms. There is a bi-directional relationship between gut microbiota modulation of bile acid-signaling properties, and their effects on gut microbiota composition. Evidence, primarily from rodent models and limited human trials, suggest that dietary modulation of the gut microbiome significantly impacts bile acid metabolism and subsequently host physiological response(s). Available evidence suggests that the link between diet, gut microbiota, and CVD risk is potentially mediated via bile acid effects on diverse metabolic pathways. However, further studies are needed to confirm/expand and translate these findings in a clinical setting.
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页数:12
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