Frequency of Depressive Syndromes in Elderly Individuals with No Cognitive Impairment, Mild Cognitive Impairment, and Alzheimer's Disease Dementia in a Memory Clinic Setting

被引:5
作者
Lee, Jun Ho [1 ]
Byun, Min Soo [1 ,2 ]
Yi, Dahyun [1 ]
Choe, Young Min [3 ]
Choi, Hyo Jung [1 ,2 ]
Baek, Hyewon [1 ]
Sohn, Bo Kyung [2 ,4 ]
Kim, Hyun Jung [1 ]
Lee, Younghwa [1 ]
Woo, Jong Inn [5 ]
Lee, Dong Young [1 ,2 ]
机构
[1] Seoul Natl Univ Hosp, Dept Neuropsychiat, Seoul, South Korea
[2] Seoul Natl Univ, Coll Med, Dept Neuropsychiat, Seoul, South Korea
[3] Univ Ulsan, Ulsan Univ Hosp, Coll Med, Dept Neuropsychiat, Ulsan, South Korea
[4] Seoul Natl Univ, SMG SNU Boramae Med Ctr, Dept Neuropsychiat, Seoul, South Korea
[5] Seoul Natl Univ, Med Res Ctr, Inst Human Behav Med, Seoul, South Korea
关键词
Depression; Alzheimer's disease; Epidemiology; NEUROPSYCHIATRIC SYMPTOMS; CEREBROVASCULAR-DISEASE; ASSESSMENT BATTERY; MINOR DEPRESSION; MAJOR DEPRESSION; RISK-FACTORS; PREVALENCE; SERTRALINE; PROGRESSION; CONSORTIUM;
D O I
10.1159/000449155
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Aims: The aims of this study were to investigate the frequency of various depressive syndromes in elderly individuals with no cognitive impairment (NC), mild cognitive impairment (MCI), and Alzheimer's disease dementia (AD) in a memory clinic setting, and then to test whether severe and milder forms of depressive syndromes are differentially associated with the cognitive groups. Methods: For 216 NC, 478 MCI, and 316 AD subjects, we investigated the frequency of depressive syndromes, defined by three different categories: major and minor depressive disorder (MaDD and MiDD) according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, as well as depression according to the National Institute of Mental Health provisional diagnostic criteria for depression in Alzheimer's disease (NIMH-dAD). Results: The frequency of MaDD did not show any significant difference among NC, MCI, and AD. In contrast, the frequencies of MiDD and NIMH-dAD were higher than those of MaDD and showed significant group differences with a gradual increase from NC to AD. Conclusion: The findings suggest that the degenerative process of Alzheimer's disease contributes to the occurrence of mild depressive conditions, but not to severe depression. (C) 2016 S. Karger AG, Basel
引用
收藏
页码:135 / 145
页数:11
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