X-ray diffraction and electron microscopy in the polymorphism study of ondansetron hydrochloride

被引：5

作者：

Llácer, JM

Gallardo, V

Delgado, R

Párraga, J

Martin, D

Ruiz, MA ^{[1
]}

机构：

[1] Univ Granada, Fac Pharm, Dept Pharm & Pharmaceut Technol, E-18071 Granada, Spain

[2] Univ Granada, Dept Edaphol & Agr Chem, E-18071 Granada, Spain

[3] Univ Granada, Dept Mineral & Petrol, E-18071 Granada, Spain

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2001年 / 27卷 / 09期

关键词：

ondansetron hydrochloride; polymorphs; scanning electron microscopy; X-ray diffraction;

D O I：

10.1081/DDC-100107670

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using different techniques, we studied the possible formation of ondansetron polymorphs. Ondansetron is a carbazol antiemetic that acts as a competitive, selective inhibitor of 5-HT3 serotonin receptors. The polymorphs were determined by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results suggest that the compounds are not true crystallographic polymorphs, but instead are the product of physical structural changes in the drug, which would be of interest pharmaceutically.

引用

页码：899 / 908

页数：10

共 8 条

[1]

BLACKWELL CP, 1989, EUR J CANCER CLIN ON, V25, pS21

[2] SELECTIVITY OF 5-HT3 RECEPTOR ANTAGONISTS AND ANTIEMETIC MECHANISMS OF ACTION [J].