Separation of the enantiomers of four chiral drugs by neutral cyclodextrin-mediated capillary zone electrophoresis

被引：10

作者：

Ren, XQ

Dong, YY

Huang, AJ

Sun, YL ^{[1
]}

Sun, ZP

机构：

[1] Peking Univ, Dept Chem, Beijing 100871, Peoples R China

[2] Natl Inst Control Pharmaceut & Biol Prod, Beijing 100050, Peoples R China

来源：

CHROMATOGRAPHIA | 1999年 / 49卷 / 7-8期

关键词：

capillary electrophoresis; chiral separation; neutral cyclodextrins; clorprenaline and other chiral drugs;

D O I：

10.1007/BF02467615

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Neutral cyclodextrin (CD)-modified capillary zone electrophoresis (CZE) has been applied to the chiral separation of four basic drugs - clorprenaline, benzhexol, esmolol and terazosin. Selector screening and concentration optimization experiments were performed. The resolution was 3.9 for clorprenaline, 2.3 for benzhexol, 3.1 for esmolol and 1.2 for terazosin when the running electrolyte was 60 mM hydroxypropyl-beta-CD, 15 mM heptakis (2,3,6-Tri-O-methyl)-beta-CD, 60 mM gamma-CD and 60 mM heptakis (2,6-di-O-methyl)-beta-CD, respectively, in 50 mM, pH 2.5 sodium phosphate buffer.

引用

页码：411 / 414

页数：4

共 12 条

[1]

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[2] ENANTIOMERIC RESOLUTION OF CHIRAL IMIDAZOLE DERIVATIVES USING CAPILLARY ELECTROPHORESIS WITH CYCLODEXTRIN-TYPE BUFFER MODIFIERS [J].