Separation of the enantiomers of four chiral drugs by neutral cyclodextrin-mediated capillary zone electrophoresis

被引：10
|
作者：
Ren, XQ
Dong, YY
Huang, AJ
Sun, YL [1 ]
Sun, ZP
机构：
[1] Peking Univ, Dept Chem, Beijing 100871, Peoples R China
[2] Natl Inst Control Pharmaceut & Biol Prod, Beijing 100050, Peoples R China
来源：
CHROMATOGRAPHIA | 1999年 / 49卷 / 7-8期
关键词：
capillary electrophoresis; chiral separation; neutral cyclodextrins; clorprenaline and other chiral drugs;
D O I：
10.1007/BF02467615
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Neutral cyclodextrin (CD)-modified capillary zone electrophoresis (CZE) has been applied to the chiral separation of four basic drugs - clorprenaline, benzhexol, esmolol and terazosin. Selector screening and concentration optimization experiments were performed. The resolution was 3.9 for clorprenaline, 2.3 for benzhexol, 3.1 for esmolol and 1.2 for terazosin when the running electrolyte was 60 mM hydroxypropyl-beta-CD, 15 mM heptakis (2,3,6-Tri-O-methyl)-beta-CD, 60 mM gamma-CD and 60 mM heptakis (2,6-di-O-methyl)-beta-CD, respectively, in 50 mM, pH 2.5 sodium phosphate buffer.
引用
收藏
页码：411 / 414
页数：4
相关论文
共 50 条
  • [1] Separation of the enantiomers of four chiral drugs by neutral cyclodextrin-mediated capillary zone electrophoresis
    Department of Chemistry, Peking University, Beijing 100871, China
    不详
    Chromatographia, 7-8 (411-414):
  • [2] Separation of the enantiomers of four chiral drugs by neutral cyclodextrin-mediated capillary zone electrophoresis
    Xueqin Ren
    Yiyang Dong
    Aijin Huang
    Yiliang Sun
    Zengpei Sun
    Chromatographia, 1999, 49 : 411 - 414
  • [3] Enantioseparation of Chiral Drugs by Cyclodextrin-Mediated Capillary Zone Electrophoresis
    Zhang Zhi-Chao
    Zhang Kai
    Jiang Zheng-Jin
    Zhou Qi-lin
    Wang Qin-Sun
    Gao Ru-Yu
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2001, 22 : 42 - 44
  • [4] Enantioseparation of Chiral Drugs by Cyclodextrin-Mediated Capillary Zone Electrophoresis
    Zhang, Zhi-Chao
    Zhang, Kai
    Jiang, Zheng-Jin
    Zhou, Qi-Lin
    Wang, Qin-Sun
    Gao, Ru-Yu
    Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities, 2001, 22 (10 SUPPL.):
  • [5] DIRECT SEPARATION OF THE ENANTIOMERS OF BETA-BLOCKERS BY CYCLODEXTRIN-MEDIATED CAPILLARY ZONE ELECTROPHORESIS
    QUANG, CY
    KHALEDI, MG
    HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY, 1994, 17 (02): : 99 - 101
  • [6] EXTENDING THE SCOPE OF CHIRAL SEPARATION OF BASIC COMPOUNDS BY CYCLODEXTRIN-MEDIATED CAPILLARY ZONE ELECTROPHORESIS
    QUANG, CY
    KHALEDI, MG
    JOURNAL OF CHROMATOGRAPHY A, 1995, 692 (1-2) : 253 - 265
  • [7] CHIRAL SEPARATION OF CETIRIZINE ENANTIOMERS BY CYCLODEXTRIN MEDIATED CAPILLARY ELECTROPHORESIS
    Hancu, Gabriel
    Budau, Monica
    Papp, Lajos Attila
    Rusu, Aura
    Mircia, Eleonora
    INDONESIAN JOURNAL OF PHARMACY, 2014, 25 (04): : 223 - 229
  • [8] Enantiomeric separation of amphetamine and phenylephrine by cyclodextrin-mediated capillary zone electrophoresis
    Department of Chemistry, Peking University, Beijing 100871, China
    不详
    J. Chromatogr. A, 1-2 (295-301):
  • [9] Separation of positional and structural isomers by cyclodextrin-mediated capillary zone electrophoresis
    Lucy, CA
    Brown, R
    Yeung, KKC
    JOURNAL OF CHROMATOGRAPHY A, 1996, 745 (1-2) : 9 - 15
  • [10] Enantiomeric separation of amphetamine and phenylephrine by cyclodextrin-mediated capillary zone electrophoresis
    Wang, Z
    Sun, YL
    Sun, ZP
    JOURNAL OF CHROMATOGRAPHY A, 1996, 735 (1-2) : 295 - 301
12345