The neuroanatomy and neurochemistry of sleep-wake control

被引:19
作者
Gompf, Heinrich S. [1 ]
Anaclet, Christelle [1 ]
机构
[1] Univ Massachusetts, Sch Med, Dept Neurobiol, Worcester, MA 01605 USA
基金
美国国家卫生研究院;
关键词
GABAERGIC PARAFACIAL ZONE; EYE-MOVEMENT SLEEP; BASAL FOREBRAIN; REM-SLEEP; CHOLINERGIC CIRCUITS; NEURONS; WAKEFULNESS; NUCLEUS; BRAIN; ACTIVATION;
D O I
10.1016/j.cophys.2019.12.012
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Sleep-wake control is dependent upon multiple brain areas widely distributed throughout the neural axis. Historically, the monoaminergic and cholinergic neurons of the ascending arousal system were the first to be discovered, and it was only relatively recently that GABAergic and glutamatergic wake-promoting and sleep-promoting populations have been identified. Contemporary advances in molecular-genetic tools have revealed both the complexity and heterogeneity of GABAergic NREM sleep-promoting neurons as well as REM sleep-regulating populations in the brainstem such as glutamatergic neurons in the sublaterodorsal nucleus.
引用
收藏
页码:143 / 151
页数:9
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