TNFα is responsible for the canonical offspring number-size trade-off

被引:7
|
作者
Maslennikova, S. O. [1 ]
Gerlinskaya, L. A. [1 ]
Kontsevaya, G., V [1 ]
Anisimova, M., V [1 ]
Nedospasov, S. A. [2 ,3 ]
Feofanova, N. A. [4 ]
Moshkin, M. P. [1 ]
Moshkin, Y. M. [1 ,5 ]
机构
[1] Russian Acad Sci, Siberian Branch, Fed Res Ctr, Inst Cytol & Genet, Novosibirsk, Russia
[2] Lomonosov Moscow State Univ, Moscow, Russia
[3] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow, Russia
[4] Res Inst Fundamental & Clin Immunol, Novosibirsk, Russia
[5] Russian Acad Sci, Siberian Branch, Inst Mol & Cellular Biol, Novosibirsk, Russia
关键词
CYTOKINES; IMMUNE; GROWTH; MODEL; LIFE; MASS; MICE;
D O I
10.1038/s41598-019-38844-9
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
There is a canonical life-history trade-off between quantity and quality of offspring, but molecular determinants for this are unknown. Here, we show that knockout of tumor necrosis factor (TNF-KO) in mice switched a relation between the number and size of developing embryos from expectedly negative to unexpectedly positive. Depletion of TNF alpha imbalanced humoral and trophic maintenance of embryo growth during gestation with respect to the litter size. The levels of embryotrophic GM-CSF cytokine and placental efficiency attained positive correlations with the number and size of embryos in TNF-KO females. Thus, TNF alpha oversees mother's resource allocations to balance embryo growth with the number of offspring. Consequently, this suggests an intricate link between the number-size trade-off and immunity given a pivotal role of TNF alpha in immune homeostasis.
引用
收藏
页数:8
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