Brain MR spectroscopy in autism spectrum disorder- the GABA excitatory/inhibitory imbalance theory revisited

被引：43

作者：

Brix, Maiken K. ^{[1
,2
]}

Ersland, Lars ^{[3
,4
]}

Hugdahl, Kenneth ^{[1
,4
,5
,6
]}

Gruner, Renate ^{[1
,4
,7
]}

Posserud, Maj-Britt ^{[8
]}

Hammar, Asa ^{[5
]}

Craven, Alexander R. ^{[4
,5
]}

Noeske, Ralph ^{[9
]}

Evans, C. John ^{[10
]}

Walker, Hanne B. ^{[11
]}

Midtvedt, Tore ^{[12
]}

Beyer, Mona K. ^{[13
,14
]}

机构：

[1] Haukeland Hosp, Dept Radiol, Postboks 1400, N-5021 Bergen, Norway

[2] Univ Bergen, Dept Clin Med K1, Bergen, Norway

[3] Haukeland Hosp, Dept Clin Engn, N-5021 Bergen, Norway

[4] Univ Bergen, NORMENT KG Jebsen Ctr Mental Disorders Res, Bergen, Norway

[5] Univ Bergen, Dept Biol & Med Psychol, Bergen, Norway

[6] Haukeland Hosp, Div Psychiat, N-5021 Bergen, Norway

[7] Univ Bergen, Dept Phys & Technol, Bergen, Norway

[8] Haukeland Hosp, Dept Child & Adolescent Psychiat, N-5021 Bergen, Norway

[9] GE Healthcare, MR Applicat & Workflow Dev, Berlin, Germany

[10] Cardiff Univ, Sch Psychol, CUBRIC, Cardiff CF10 3AX, S Glam, Wales

[11] Univ Oslo, Fac Math & Nat Sci, Oslo, Norway

[12] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden

[13] Oslo Univ Hosp, Dept Radiol & Nucl Med, Oslo, Norway

[14] Oslo & Akershus Univ Coll Appl Sci, Dept Life Sci & Hlth, Fac Hlth Sci, Oslo, Norway

来源：

FRONTIERS IN HUMAN NEUROSCIENCE | 2015年 / 9卷

关键词：

ASD; GABA; MRS; MEGA-PRESS; ASSQ; MAGNETIC-RESONANCE-SPECTROSCOPY; ASPERGER-SYNDROME; CINGULATE CORTEX; CEREBRAL GABA; CHILDREN; DYSFUNCTION; QUESTIONNAIRE; ABNORMALITIES; METAANALYSIS; PREVALENCE;

D O I：

10.3389/fnhum.2015.00365

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of gamma-aminobutyric acid (GABA) between the two groups, and to investigate the relationship between brain metabolites and autism symptom severity in the ASD group. We did find a significant negative correlation in the ASD group between Autism Spectrum Screening Questionnaire (ASSQ) and GABA+/Cr, which may imply that severity of symptoms in ASD is associated with differences in the level of GABA in the brain, supporting the excitatory/inhibitory (E/I) imbalance theory. However we did not find a significant difference between the two groups in GABA levels.

引用

页数：12

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