Excessive serous retinal detachment during the use of isotretinoin

Purpose To report a case unilateral excessive subretinal fluid during the use of isotretinoin. Method A case report. A patient who used isotretinoin orally for nodular-cystic acne vulgaris developed concurrent unilaterally excessive subretinal fluid and serous retinal detachment. Results Fluorescein angiography did not demonstrate the leakage points throughout the subretinal fluid. Spectral-domain optical coherence tomography showed the excessive subretinal fluid and serous retinal detachment at macula. Two weeks after presentation, visual acuity was partially increased and subretinal fluid was disappeared at macula. Conclusion Isotretinoin may affect the functioning of the RPE and can cause the development of subretinal fluid and serous retinal detachment.